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- Title
Palladium-Catalyzed Carboxylation of Benzyl Chlorides with Atmospheric Carbon Dioxide in Combination with Manganese/Magnesium Chloride.
- Authors
Zhang, Shuai; Chen, Wei‐Qiang; Yu, Ao; He, Liang‐Nian
- Abstract
An efficient direct carboxylation of a series of benzyl chlorides with CO2 catalyzed by Pd(OAc)2/dicyclohexyl (2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine (SPhos) was developed to afford the corresponding phenylacetic acids in combination with Mn powder as a reducing reagent and MgCl2 as an indispensable additive. The reaction proceeded smoothly under 1 atm CO2. The application of Mn powder instead of a sensitive reducing reagent represents an operationally simple access to phenylacetic acids. Notably, MgCl2 is able to stabilize the (SPhos)2PdII(Bn)(Cl)(η¹-CO2)(MgCl2) adduct and thus facilitates CO2 insertion into the PdII-C bond, which is supported by a DFT study.
- Subjects
PALLADIUM catalysts; CARBOXYLATION; BENZYL chloride; ATMOSPHERIC carbon dioxide; MANGANESE chlorides; MAGNESIUM chloride
- Publication
ChemCatChem, 2015, Vol 7, Issue 23, p3972
- ISSN
1867-3880
- Publication type
Academic Journal
- DOI
10.1002/cctc.201500724