We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hypercoagulable states in patients with leg ischaemia.
- Authors
Ray, S. A.; Rowley, M. R.; Loh, A.; Talbot, S. A.; Bevan, D. H.; Taylor, R. S.; Dormandy, J. A.
- Abstract
Hypercoagulable states are found in up to 10 per cent of patients with a history of unexplained venous thrombosis. To investigate the prevalence in arterial thrombosis, thrombophilia screening was performed on 124 patients who had previously undergone lower-limb revascularization, 45 claudicants and 27 controls. Of the patients who had undergone revascularization 40 per cent had a hyper-coagulation abnormality (low levels of protein C, protein S and antithrombin III or presence of the lupus anti-coagulant) in comparison with 27 per cent of claudicants and 11 per cent of controls ( P < 0·01). Furthermore, patients who had suffered reocclusion after revascularization were significantly more likely to have a hypercoagulation abnormality than those who had not ( P < 0·05), even if the occlusion had occurred more than 6 months previously. Lupus anticoagulant was the abnormality most frequently detected and, like low protein C levels, was found only in patients with peripheral vascular disease. It appears that hypercoagulable states are common in patients with arterial disease and may predispose to failure of revascularization.
- Publication
British Journal of Surgery, 1994, Vol 81, Issue 6, p811
- ISSN
0007-1323
- Publication type
Academic Journal
- DOI
10.1002/bjs.1800810607