Title: A natural heme deficiency exists in biology that allows nitric oxide to control heme protein functions by regulating cellular heme distribution.
Authors: Stuehr, Dennis J.; Biswas, Pranjal; Dai, Yue; Ghosh, Arnab; Islam, Sidra; Jayaram, Dhanya Thamaraparambil
Abstract: A natural heme deficiency that exists in cells outside of the circulation broadly compromises the heme contents and functions of heme proteins in cells and tissues. Recently, we found that the signaling molecule, nitric oxide (NO), can trigger or repress the deployment of intracellular heme in a concentration‐dependent hormetic manner. This uncovers a new role for NO and sets the stage for it to shape numerous biological processes by controlling heme deployment and consequent heme protein functions in biology.
Subjects: HEMOPROTEINS; HEME; CELL physiology; NITRIC oxide; BIOLOGY
Publication: BioEssays, 2023, Vol 45, Issue 8, p1
ISSN: 0265-9247
Publication type: Academic Journal
DOI: 10.1002/bies.202300055

A natural heme deficiency exists in biology that allows nitric oxide to control heme protein functions by regulating cellular heme distribution.

Stuehr, Dennis J.; Biswas, Pranjal; Dai, Yue; Ghosh, Arnab; Islam, Sidra; Jayaram, Dhanya Thamaraparambil