Ruthenium(II) complexes derived from C₂-symmetric ferrocene-based chiral bis(phosphinite) ligands: synthesis and.

Ak, B.; Durap, F.; Aydemir, M.; Baysal, A.

Chiral secondary alcohols are very important and valuable both in organic synthesis and in the pharmaceutical industry for producing complex molecules. A series of new chiral Ru-phosphinite complexes ( 1, 2, 3, 4, 5, 6, 7, 8) were prepared from chiral C2-symmetric ferrocenyl phosphinites and corresponding chloro complex, [Ru(η6- p-cymene)(μ-Cl)Cl]2. The complexes were characterized using conventional spectroscopic methods. The binuclear complexes were tested as pre-catalysts and were found to be good pre-catalysts for the of substituted acetophenones in basic 2-propanol at 82°C, providing the corresponding optically active alcohols with almost quantitative conversion and modest to high (46-97%). Amongst the all complexes, complex 6 gave the highest ee of 97% in the reduction of 2-methoxyacetophenone to ( S)-1-(2-methoxyphenyl)ethanol at 82°C. Copyright © 2015 John Wiley & Sons, Ltd.

RUTHENIUM; LIGANDS (Chemistry); ORGANIC synthesis research; ACETOPHENONE; ETHANOL

Applied Organometallic Chemistry, 2015, Vol 29, Issue 11, p764

0268-2605

Academic Journal

10.1002/aoc.3364