Works matching DE "BIOISOSTERES"

Results: 113

Cover Feature: Facile Conversion of Molecularly Complex (Hetero)aryl Carboxylic Acids into Alkynes for Accelerated SAR Exploration (Chem. Eur. J. 60/2021).

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 60, p. 14786, doi. 10.1002/chem.202103635

By:

Lutter, Ferdinand H.;
Jouffroy, Matthieu

Publication type:

Article

Facile Conversion of Molecularly Complex (Hetero)aryl Carboxylic Acids into Alkynes for Accelerated SAR Exploration.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 60, p. 14816, doi. 10.1002/chem.202102130

By:

Lutter, Ferdinand H.;
Jouffroy, Matthieu

Publication type:

Article

Bioisosteric Exchange of C.

Published in:

Angewandte Chemie, 2016, v. 128, n. 12, p. 4117, doi. 10.1002/ange.201511672

By:

Krautwald, Simon;
Nilewski, Christian;
Mori, Mihoko;
Shiomi, Kazuro;
Ōmura, Satoshi;
Carreira, Erick M.

Publication type:

Article

Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere.

Published in:

Angewandte Chemie, 2016, v. 128, n. 11, p. 3644, doi. 10.1002/ange.201510675

By:

Chalmers, Benjamin A.;
Xing, Hui;
Houston, Sevan;
Clark, Charlotte;
Ghassabian, Sussan;
Kuo, Andy;
Cao, Benjamin;
Reitsma, Andrea;
Murray, Cody‐Ellen P.;
Stok, Jeanette E.;
Boyle, Glen M.;
Pierce, Carly J.;
Littler, Stuart W.;
Winkler, David A.;
Bernhardt, Paul V.;
Pasay, Cielo;
De Voss, James J.;
McCarthy, James;
Parsons, Peter G.;
Walter, Gimme H.

Publication type:

Article

Copper-Catalyzed Asymmetric Synthesis of Tertiary α-Hydroxy Phosphonic Acid Derivatives with In Situ Generated Nitrosocarbonyl Compounds as the Oxygen Source.

Published in:

Angewandte Chemie, 2014, v. 126, n. 52, p. 14700, doi. 10.1002/ange.201408893

By:

Maji, Biplab;
Yamamoto, Hisashi

Publication type:

Article

Simple Sulfinate Synthesis Enables CH Trifluoromethylcyclopropanation.

Published in:

Angewandte Chemie, 2014, v. 126, n. 37, p. 10009, doi. 10.1002/ange.201406622

By:

Gianatassio, Ryan;
Kawamura, Shuhei;
Eprile, Cecil L;
Foo, Klement;
Ge, Jason;
Burns, Aaron C.;
Collins, Michael R.;
Baran, Phil S.

Publication type:

Article

Benzenesulfonamides act as open-channel blockers on KV3.1 potassium channel.

Published in:

Amino Acids, 2019, v. 51, n. 2, p. 355, doi. 10.1007/s00726-018-2669-5

By:

Bassetto Junior, Carlos Alberto Zanutto;
Passianoto, Luana Vitorino Gushiken;
González, Eduardo René Pérez;
Varanda, Wamberto Antonio

Publication type:

Article

BIOISOSTERS' IMPACT ON WINE CONDITIONING.

Published in:

Lucrari Stiintifice, Universitatea de Stiinte Agricole Si Medicina Veterinara Ion Ionescu de la Brad Iasi, Seria Horticultura, 2024, v. 67, n. 1, p. 97

By:

Roxana, TUCALIUC;
Ioana, BUȚERCHI;
Marius, NICULAUA;
V., COTEA Valeriu

Publication type:

Article

BoBER: web interface to the base of bioisosterically exchangeable replacements.

Published in:

Journal of Cheminformatics, 2017, v. 9, n. 1, p. 1, doi. 10.1186/s13321-017-0251-x

By:

Lešnik, Samo;
Škrlj, Blaž;
Eržen, Nika;
Bren, Urban;
Gobec, Stanislav;
Konc, Janez;
Janežič, Dušanka

Publication type:

Article

Difluoromethyl Nitrile Oxide (CF2HCNO): A Neglected Chemical Reagent.

Published in:

European Journal of Organic Chemistry, 2017, v. 2017, n. 27, p. 3935, doi. 10.1002/ejoc.201700764

By:

Khutorianskyi, Andrii;
Chalyk, Bohdan;
Borysko, Petro;
Kondratiuk, Anna;
Mykhailiuk, Pavel K.

Publication type:

Article

Synthesis and Biological Evaluation of Migrastatin Macrotriazoles.

Published in:

European Journal of Organic Chemistry, 2017, v. 2017, n. 1, p. 60, doi. 10.1002/ejoc.201600988

By:

Gabba, Adele;
Robakiewicz, Stefania;
Taciak, Bartłomiej;
Ulewicz, Katarzyna;
Broggini, Gianluigi;
Rastelli, Giulio;
Krol, Magadalena;
Murphy, Paul V.;
Passarella, Daniele

Publication type:

Article

4′-Selenonucleosides as Next-Generation Nucleosides.

Published in:

European Journal of Organic Chemistry, 2015, v. 2015, n. 28, p. 6115, doi. 10.1002/ejoc.201500429

By:

Sahu, Pramod K.;
Naik, Siddhi D.;
Yu, Jinha;
Jeong, Lak Shin

Publication type:

Article

Synthesis of [(1,2,3-Triazol-1-yl)methyl]boronic Acids Through Click Chemistry: Easy Access to a Potential Scaffold for Protease Inhibitors.

Published in:

European Journal of Organic Chemistry, 2015, v. 2015, n. 5, p. 1075, doi. 10.1002/ejoc.201403408

By:

Romagnoli, Chiara;
Caselli, Emilia;
Prati, Fabio

Publication type:

Article

Role of Side-Chain Bioisosteres in Determining the Binding Affinity of Click Chemistry Derived RGD Peptidomimetics to αvβ3 Integrin.

Published in:

European Journal of Organic Chemistry, 2014, v. 2014, n. 34, p. 7595, doi. 10.1002/ejoc.201403129

By:

Fabbrizzi, Pierangelo;
Menchi, Gloria;
Raspanti, Silvia;
Guarna, Antonio;
Trabocchi, Andrea

Publication type:

Article

Melatonin and its bioisosteres as potential therapeutic agents for the treatment of retinopathy of prematurity.

Published in:

Chemical Biology & Drug Design, 2024, v. 103, n. 3, p. 1, doi. 10.1111/cbdd.14504

By:

Osipova, N. A.;
Panova, A. Y.;
Efremov, A. M.;
Lozinskaya, N. A.;
Beznos, O. V.;
Katargina, L. A.

Publication type:

Article

Sulfonimidamides and Imidosulfuric Diamides: Compounds from an Underexplored Part of Biologically Relevant Chemical Space.

Published in:

Chemistry - A European Journal, 2019, v. 25, n. 28, p. 6928, doi. 10.1002/chem.201900440

By:

Zasukha, Sergiy V.;
Timoshenko, Vadim M.;
Tolmachev, Andrey A.;
Pivnytska, Valentyna O.;
Gavrylenko, Oleksii;
Zhersh, Serhii;
Shermolovich, Yuriy;
Grygorenko, Oleksandr O.

Publication type:

Article

Lithium-Catalyzed Thiol Alkylation with Tertiary and Secondary Alcohols: Synthesis of 3-Sulfanyl-Oxetanes as Bioisosteres.

Published in:

Chemistry - A European Journal, 2018, v. 24, n. 4, p. 818, doi. 10.1002/chem.201705576

By:

Croft, Rosemary A.;
Mousseau, James J.;
Chulho Choi;
Bull, James A.

Publication type:

Article

Second Generation Grp94-Selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer.

Published in:

Chemistry - A European Journal, 2017, v. 23, n. 62, p. 15775, doi. 10.1002/chem.201703398

By:

Crowley, Vincent M.;
Huard, Dustin J. E.;
Lieberman, Raquel L.;
Blagg, Brian S. J.

Publication type:

Article

Benzyl Mono- P-Fluorophosphonate and Benzyl Penta- P-Fluorophosphate Anions Are Physiologically Stable Phosphotyrosine Mimetics and Inhibitors of Protein Tyrosine Phosphatases.

Published in:

Chemistry - A European Journal, 2017, v. 23, n. 61, p. 15387, doi. 10.1002/chem.201701204

By:

Wagner, Stefan;
Accorsi, Matteo;
Rademann, Jörg

Publication type:

Article

α-Amino Acid-Isosteric α-Amino Tetrazoles.

Published in:

Chemistry - A European Journal, 2016, v. 22, n. 9, p. 3009, doi. 10.1002/chem.201504520

By:

Zhao, Ting;
Kurpiewska, Katarzyna;
Kalinowska‐Tłuścik, Justyna;
Herdtweck, Eberhardt;
Dömling, Alexander

Publication type:

Article

Synthesis, Antiproliferative Activity, and ADME Profiling of Novel Racemic and Optically Pure Aryl-Substituted Purines and Purine Bioisosteres.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 3, p. 351, doi. 10.3390/biom15030351

By:

Piškor, Martina;
Milić, Astrid;
Koštrun, Sanja;
Majerić Elenkov, Maja;
Grbčić, Petra;
Kraljević Pavelić, Sandra;
Pavelić, Krešimir;
Raić-Malić, Silvana

Publication type:

Article

Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres.

Published in:

Frontiers in Pharmacology, 2015, p. 1, doi. 10.3389/fphar.2015.00155

By:

Carbonara, Roberta;
Carocci, Alessia;
Roussel, Julien;
Crescenzo, Giuseppe;
Buonavoglia, Canio;
Franchini, Carlo;
Lentini, Giovanni;
Camerino, Diana Conte;
Desaphy, Jean-François;
Kellenberger, Stephan;
Suter, Marc R.

Publication type:

Article

Highly Efficient and Stereoselective Synthesis of 6,7‐Dideoxy‐β‐d‐ido‐octopyranuronates.

Published in:

European Journal of Organic Chemistry, 2022, v. 2022, n. 32, p. 1, doi. 10.1002/ejoc.202200175

By:

Homayonia, Saba;
Ling, Chang‐Chun

Publication type:

Article

Bioisosteric modification on benzylidene‐carbonyl compounds improved the drug‐likeness and maintained the antifungal activity against Sporothrix brasiliensis.

Published in:

Chemical Biology & Drug Design, 2022, v. 99, n. 3, p. 391, doi. 10.1111/cbdd.13994

By:

Waller, Stefanie Bressan;
Cleff, Marlete Brum;
Ripoll, Márcia Kutscher;
Meireles, Mário Carlos Araújo;
Ferrarini, Márcio;
Varela, Marina Themoteo;
Fernandes, João Paulo S.

Publication type:

Article

Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening.

Published in:

Chemical Biology & Drug Design, 2016, v. 88, n. 2, p. 178, doi. 10.1111/cbdd.12744

By:

Zhang, Wei;
Zhai, Ling;
Lu, Wenyan;
Boohaker, Rebecca J.;
Padmalayam, Indira;
Li, Yonghe

Publication type:

Article

Sirtuins are Unaffected by PARP Inhibitors Containing Planar Nicotinamide Bioisosteres.

Published in:

Chemical Biology & Drug Design, 2016, v. 87, n. 3, p. 478, doi. 10.1111/cbdd.12680

By:

Ekblad, Torun;
Schüler, Herwig

Publication type:

Article

SEAL by NMR: Glyco-Based Selenium-Labeled Affinity Ligands Detected by NMR Spectroscopy.

Published in:

Chemistry - A European Journal, 2014, v. 20, n. 43, p. 13905, doi. 10.1002/chem.201404933

By:

Hamark, Christoffer;
Landström, Jens;
Widmalm, Göran

Publication type:

Article

Synthetic studies on the tetrasubstituted D-ring of cystobactamids lead to potent terephthalic acid antibiotics.

Published in:

Communications Chemistry, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42004-024-01337-6

By:

Stappert, Moritz;
Kohnhäuser, Daniel;
Seedorf, Tim;
Coetzee, Janetta;
Rox, Katharina;
Fuchs, Hazel L. S.;
Cirnski, Katarina;
Leitner, Christian;
Herrmann, Jennifer;
Kirschning, Andreas;
Müller, Rolf;
Brönstrup, Mark

Publication type:

Article

A Review of Pharmacological Activities of [1,2,4]- Oxadiazoles.

Published in:

International Journal of Pharmaceutical Research (09752366), 2020, p. 1299, doi. 10.31838/ijpr/2020.SP2.121

By:

AGGARWAL, SUNAINA;
GOYAL, ANJU;
KAUR, RAJWINDER;
SINGH, GURDYAL

Publication type:

Article

Annotation and curation of uncharacterized proteins- challenges.

Published in:

Frontiers in Genetics, 2015, v. 6, p. 1, doi. 10.3389/fgene.2015.00119

By:

Ijaq, Johny;
Chandrasekharan, Mohanalatha;
Poddar, Rajdeep;
Bethi, Neeraja;
Sundararajan, Vijayaraghava S.

Publication type:

Article

Pharmacological profile of a 17β-heteroaryl-substituted neuroactive steroid.

Published in:

Psychopharmacology, 2014, v. 231, n. 17, p. 3517, doi. 10.1007/s00213-014-3494-5

By:

Hogenkamp, Derk;
Tran, Minhtam;
Yoshimura, Ryan;
Johnstone, Timothy;
Kanner, Richard;
Gee, Kelvin

Publication type:

Article

Photoredox‐Catalyzed Decarboxylative Oxidation of Arylacetic Acids.

Published in:

Chemistry - An Asian Journal, 2018, v. 13, n. 17, p. 2410, doi. 10.1002/asia.201800529

By:

Sakakibara, Yota;
Cooper, Phillippa;
Murakami, Kei;
Itami, Kenichiro

Publication type:

Article

Context-dependent similarity analysis of analogue series for structure–activity relationship transfer based on a concept from natural language processing.

Published in:

Journal of Cheminformatics, 2025, v. 17, n. 1, p. 1, doi. 10.1186/s13321-025-00951-3

By:

Yoshimori, Atsushi;
Bajorath, Jürgen

Publication type:

Article

Synthesis and antitumor activities of 3-substituted-analine derivatives: structure modifications of Tuv part of tubulysins.

Published in:

Chemistry Central Journal, 2018, v. 12, n. 1, p. 1, doi. 10.1186/s13065-018-0483-5

By:

Shao, Mingsha;
Bai, Xinfa;
Ma, Xuan;
Yan, Ning;
Yao, Lei

Publication type:

Article

Borole Ring Expansion Reactions with Boron Azides: A Versatile Pathway to Borylated Azaborinines.

Published in:

European Journal of Inorganic Chemistry, 2024, v. 27, n. 36, p. 1, doi. 10.1002/ejic.202400498

By:

Lindl, Felix;
Thiess, Torsten;
Goettel, James T.;
Dotzauer, Simon;
Ernst, Moritz Johannes;
Bélanger‐Chabot, Guillaume;
Braunschweig, Holger

Publication type:

Article

Agrochemical lead optimization by scaffold hopping.

Published in:

Pest Management Science, 2018, v. 74, n. 2, p. 282, doi. 10.1002/ps.4755

By:

Lamberth, Clemens

Publication type:

Article

Heterocyclic chemistry in crop protection.

Published in:

Pest Management Science, 2013, v. 69, n. 10, p. 1106, doi. 10.1002/ps.3615

By:

Lamberth, Clemens

Publication type:

Article

Deconstruction – Reconstruction: Analysis of the Crucial Structural Elements of GluN2B-Selective, Negative Allosteric NMDA Receptor Modulators with 3-Benzazepine Scaffold.

Published in:

Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2021, v. 55, p. 1, doi. 10.33594/00000033

By:

Ritter, Nadine;
Korff, Marvin;
Markus, Alexander;
Schepmann, Dirk;
Seebohm, Guiscard;
Schreiber, Julian A.;
Wünsch, Bernhard

Publication type:

Article

Design, synthesis, and biological evaluation of triazole-pyrimidine-methylbenzonitrile derivatives as dual A2A/A2B adenosine receptor antagonists.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 1514, doi. 10.1080/14756366.2022.2077731

By:

Zhi Li;
Lijuan Kou;
Xinzhen Fu;
Zeping Xie;
Maolei Xu;
Lin Guo;
Tiantian Lin;
Shizhou Gong;
Shumin Zhang;
Ming Liu

Publication type:

Article

1-(5-Carboxyindazol-1-yl)propan-2-ones as dual inhibitors of cytosolic phospholipase A 2 α and fatty acid amide hydrolase: bioisosteric replacement of the carboxylic acid moiety.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, p. 131, doi. 10.1080/14756366.2016.1178246

By:

Althaus, Jan;
Hake, Theresa;
Hanekamp, Walburga;
Lehr, Matthias

Publication type:

Article

Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, n. 1, p. 121, doi. 10.3109/14756366.2015.1005012

By:

Puskullu, M. Orhan;
Shirinzadeh, Hanif;
Nenni, Merve;
Gurer-Orhan, Hande;
Suzen, Sibel

Publication type:

Article

Targets of drugs are generally, and targets of drugs having side effects are specifically good spreaders of human interactome perturbations.

Published in:

Scientific Reports, 2015, p. 10182, doi. 10.1038/srep10182

By:

Perez-Lopez, Áron R.;
Szalay, Kristóf Z.;
Türei, Dénes;
Módos, Dezső;
Lenti, Katalin;
Korcsmáros, Tamás;
Csermely, Peter

Publication type:

Article

Isocyanide–Based Multicomponent Reactions Coupled One–Pot Process: Efficient Tools to Diversity–Oriented Synthesis of Structural Peptidomimetics.

Published in:

ChemPlusChem, 2024, v. 89, n. 6, p. 1, doi. 10.1002/cplu.202300633

By:

Kaveti, Bhavna;
Rentería‐Gómez, Manuel A.;
Corona‐Díaz, Alejandro;
Pharande, Shrikant G.;
Rentería‐Gómez, Ángel;
Gámez‐Montaño, Rocío

Publication type:

Article

In silico design of sitagliptin bioisosteres as new inhibitors of Mpro SARS-CoV-2.

Published in:

Journal of Applied Pharmaceutical Science, 2024, v. 14, n. 12, p. 145, doi. 10.7324/JAPS.2024.192856

By:

Abad-Giron, Abelardo;
Asmad-Cruz, Lucero;
Cordova-Muñoz, Angella M.;
Gamarra-Sanchez, Cesar D.;
Silva-Correa, Carmen R.;
Villarreal-La Torre, Víctor E.

Publication type:

Article

In silico design of new ketorolac bioisosteres as anti-inflammatory agents.

Published in:

Journal of Applied Pharmaceutical Science, 2024, v. 14, n. 4, p. 155, doi. 10.7324/JAPS.2024.162337

By:

Gamarra-Sánchez, César D.;
Rodriguez-Silva, Cristhian N.;
Cordova-Muñoz, Angella;
Asmad-Cruz, Lucero;
Silva-Correa, Carmen R.;
Villarreal-La Torre, Víctor E.

Publication type:

Article

Probing the Orthosteric Binding Site of GABA Receptors with Heterocyclic GABA Carboxylic Acid Bioisosteres.

Published in:

Neurochemical Research, 2014, v. 39, n. 6, p. 1005, doi. 10.1007/s11064-013-1226-6

By:

Petersen, Jette;
Bergmann, Rikke;
Krogsgaard-Larsen, Povl;
Balle, Thomas;
Frølund, Bente

Publication type:

Article

Synthesis of 1,2,3‐Triazole and Pyrazole Analogues as Bioisosteres of Biphenyl‐Neolignans.

Published in:

Bulletin of the Korean Chemical Society, 2018, v. 39, n. 1, p. 126, doi. 10.1002/bkcs.11352

By:

Sun, Wei;
Kim, Taek‐Soo;
Choi, Nam Song;
Seo, Seung‐Yong

Publication type:

Article

"Angular" Spirocyclic Azetidines: Synthesis, Characterization, and Evaluation in Drug Discovery.

Published in:

Angewandte Chemie, 2025, v. 137, n. 7, p. 1, doi. 10.1002/ange.202418850

By:

Kirichok, Alexander A.;
Tkachuk, Hennadii;
Levchenko, Kostiantyn;
Granat, Dmitry;
Yegorova, Tetyana;
Lesyk, Dmytro;
Anisiforova, Anna;
Holota, Yuliia;
Zomchak, Viktoriia;
Bodenchuk, Iryna;
Kosach, Viktoriia;
Borysko, Petro;
Korzh, Rodion A.;
Al‐Maali, Galeb;
Kubyshkin, Vladimir;
Rzepa, Henry S.;
Mykhailiuk, Pavel K.

Publication type:

Article

Strain‐Release‐Driven Modular Synthesis of Oxetane‐Based Amide Bioisosteres: Concise, Robust and Scalable Approach.

Published in:

Angewandte Chemie, 2024, v. 136, n. 42, p. 1, doi. 10.1002/ange.202410554

By:

Spránitz, Péter;
Sőregi, Petra;
Hegedüs, Kristóf;
Igriczi, Barbara;
Szakács, Gergely;
Jemnitz, Katalin;
Szabó, Pál;
Galushchak, Yarema;
Mykhailiuk, Pavel K.;
Soós, Tibor

Publication type:

Article

Overcoming a Radical Polarity Mismatch in Strain‐Release Pentafluorosulfanylation of [1.1.0]Bicyclobutanes: An Entryway to Sulfone‐ and Carbonyl‐Containing SF5‐Cyclobutanes.

Published in:

Angewandte Chemie, 2024, v. 136, n. 19, p. 1, doi. 10.1002/ange.202319930

By:

Kraemer, Yannick;
Buldt, Jón Atiba;
Kong, Wang‐Yeuk;
Stephens, Alexander M.;
Ragan, Abbey N.;
Park, Soojun;
Haidar, Zane C.;
Patel, Ansh Hiten;
Shey, Rachel;
Dagan, Roee;
McLoughlin, Connor P.;
Fettinger, James C.;
Tantillo, Dean J.;
Pitts, Cody Ross

Publication type:

Article