Use of Three-Dimensional Arterial Models To Predict the In Vivo Behavior of Nanoparticles for Drug Delivery.

Chetprayoon, Paninee; Matsusaki, Michiya; Yokoyama, Utako; Tejima, Takanori; Ishikawa, Yoshihiro; Akashi, Mitsuru

Nanomaterials have been widely used for applications in biomedical fields and could become indispensable in the near future. However, since it is difficult to optimize in vivo biological behavior in a 3D environment by using a single cell in vitro, there have been many failures in animal models. In vitro prediction systems using 3D human-tissue models reflecting the 3D location of cell types may be useful to better understand the biological characteristics of nanomaterials for optimization of their function. Herein we demonstrate the potential ability of 3D engineered human-arterial models for in vitro prediction of the in vivo behavior of nanoparticles for drug delivery. These models enabled optimization of the composition and size of the nanoparticles for targeting and treatment efficacy for atherosclerosis. In vivo experiments with atherosclerotic mice suggested excellent biological characteristics and potential treatment effects of the nanoparticles optimized in vitro.

NANOMEDICINE; DRUG delivery systems; THREE-dimensional modeling; ARTERIES; ATHEROSCLEROSIS treatment; ANATOMY

Angewandte Chemie International Edition, 2016, Vol 55, Issue 14, p4461

1433-7851

Academic Journal

10.1002/anie.201509752