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- Title
The cis-Diammineplatinum(II) Complex of Curcumin: A Dual Action DNA Crosslinking and Photochemotherapeutic Agent.
- Authors
Mitra, Koushambi; Gautam, Srishti; Kondaiah, Paturu; Chakravarty, Akhil R.
- Abstract
[Pt(cur)(NH3)2](NO3) (1), a curcumin-bound cis-diammineplatinum(II) complex, nicknamed Platicur, as a novel photoactivated chemotherapeutic agent releases photoactive curcumin and an active platinum(II) species upon irradiation with visible light. The hydrolytic instability of free curcumin reduces upon binding to platinum(II). Interactions of 1 with 5'-GMP and ct-DNA indicated formation of platinum-bound DNA adducts upon exposure to visible light (λ=400--700 nm). It showed apoptotic photocytotoxicity in cancer cells (IC50≈15 µM), thus forming OH, while remaining passive in the darkness (IC50>200 µM). A comet assay and platinum estimation suggest Pt--DNA crosslink formation. The fluorescence microscopic images showed cytosolic localization of cu
- Subjects
PLATINUM compound synthesis; CURCUMIN; CELL imaging; CANCER cells; PHOTOCHEMOTHERAPY; CROSSLINKING (Polymerization)
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 47, p13989
- ISSN
1433-7851
- Publication type
Academic Journal
- DOI
10.1002/anie.201507281