Results
Title

Total Synthesis and Stereochemical Assignment of Baringolin.

Authors

Just‐Baringo, Xavier; Bruno, Paolo; Ottesen, Lars K.; Cañedo, Librada M.; Albericio, Fernando; Álvarez, Mercedes

Abstract

The thiopeptide antibiotic baringolin has been synthesized, and its structure and stereochemistry have been confirmed. The use of a strategy based on palladium‐catalyzed cross‐couplings permitted a modular construction of this natural product.

Subjects

CHEMICAL synthesis; THIOPEPTIDES; ANTIBIOTIC synthesis; STRUCTURE-activity relationships; STEREOCHEMISTRY

Publication

Angewandte Chemie International Edition, 2013, Vol 52, Issue 30, p7818

ISSN

1433-7851

Publication type

Academic Journal

DOI

10.1002/anie.201302372