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Title: One-Pot Deracemization of sec-Alcohols: Enantioconvergent Enzymatic Hydrolysis of Alkyl Sulfates Using Stereocomplementary Sulfatases.
Authors: Schober, Markus; Toesch, Michael; Knaus, Tanja; Strohmeier, Gernot A.; van Loo, Bert; Fuchs, Michael; Hollfelder, Florian; Macheroux, Peter; Faber, Kurt
Abstract: Hand in hand: The title transformation was achieved using a pair of sulfatases acting through inversion and retention of configuration on opposite substrate enantiomers. Using Pseudomonas aeruginosa arylsulfatase PAS with alkylsulfatase PISA1 in one‐pot leads to sec‐alcohols (80 to >99 % conversion) with 91 to greater than 99 % ee.
Publication: Angewandte Chemie International Edition, 2013, Vol 52, Issue 11, p3277
ISSN: 1433-7851
Publication type: Academic Journal
DOI: 10.1002/anie.201209946

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One-Pot Deracemization of sec-Alcohols: Enantioconvergent Enzymatic Hydrolysis of Alkyl Sulfates Using Stereocomplementary Sulfatases.