Results
Title

Gold(III) Complexes Containing N-Heterocyclic Carbene Ligands: Thiol 'Switch-on' Fluorescent Probes and Anti-Cancer Agents.

Authors

Zou, Taotao; Lum, Ching Tung; Chui, Stephen Sin‐Yin; Che, Chi‐Ming

Abstract

Illuminating results: Activation of non‐emissive [AuIII(N N N)(NHC)] complexes (such as 1) through reduction by intracellular glutathione gives active AuI–NHC complexes, which show promising anti‐cancer properties, accompanied by release of the highly fluorescent ligand. The high fluorescence “switch‐on” efficiency makes these AuIII complexes excellent probes for cellular thiol detection.

Publication

Angewandte Chemie International Edition, 2013, Vol 52, Issue 10, p2930

ISSN

1433-7851

Publication type

Academic Journal

DOI

10.1002/anie.201209787