Works matching DE "BIOISOSTERES"
Results: 104
3,3‐Difluorooxetane–A Versatile Functional Group for Bioisosteric Replacements in Drug Discovery.
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- Chemistry - A European Journal, 2024, v. 30, n. 72, p. 1, doi. 10.1002/chem.202403277
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- Article
Organometallic Bridge Diversification of Bicyclo[1.1.1]pentanes.
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- Chemistry - A European Journal, 2024, v. 30, n. 12, p. 1, doi. 10.1002/chem.202304070
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- Article
Scaffold Editing of Cubanes into Homocubanes, Homocuneanes via Cuneanes.
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- Chemistry - A European Journal, 2024, v. 30, n. 9, p. 1, doi. 10.1002/chem.202303063
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- Article
Enzymatic kinetic resolution of desmethylphosphinothricin indicates that phosphinic group is a bioisostere of carboxyl group.
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- Communications Chemistry, 2020, v. 3, n. 1, p. N.PAG, doi. 10.1038/s42004-020-00368-z
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Context-dependent similarity analysis of analogue series for structure–activity relationship transfer based on a concept from natural language processing.
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- Journal of Cheminformatics, 2025, v. 17, n. 1, p. 1, doi. 10.1186/s13321-025-00951-3
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- Article
Ligand-Based Design of Selective Peptidomimetic uPA and TMPRSS2 Inhibitors with Arg Bioisosteres.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 3, p. 1375, doi. 10.3390/ijms25031375
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Exploration of Diazaspiro Cores as Piperazine Bioisosteres in the Development of σ2 Receptor Ligands.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 15, p. 8259, doi. 10.3390/ijms23158259
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- Article
Non-Classical Inhibition of Carbonic Anhydrase.
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- International Journal of Molecular Sciences, 2016, v. 17, n. 7, p. 1150, doi. 10.3390/ijms17071150
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- Article
Carboxylic Acid Bioisosteres in Medicinal Chemistry: Synthesis and Properties.
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- Journal of Chemistry, 2022, p. 1, doi. 10.1155/2022/2164558
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- Article
Acceleration of Binding Site Comparisons by Graph Partitioning.
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- Molecular Informatics, 2015, v. 34, n. 8, p. 550, doi. 10.1002/minf.201500028
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- Article
Bioisosteres and Scaffold Hopping in Medicinal Chemistry.
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- Molecular Informatics, 2014, v. 33, n. 6/7, p. 458, doi. 10.1002/minf.201400037
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- Article
Synthesis and antitumor activities of 3-substituted-analine derivatives: structure modifications of Tuv part of tubulysins.
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- Chemistry Central Journal, 2018, v. 12, n. 1, p. 1, doi. 10.1186/s13065-018-0483-5
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- Article
Borole Ring Expansion Reactions with Boron Azides: A Versatile Pathway to Borylated Azaborinines.
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- European Journal of Inorganic Chemistry, 2024, v. 27, n. 36, p. 1, doi. 10.1002/ejic.202400498
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- Article
High‐performance liquid chromatographic and subcritical fluid chromatographic separation of α‐arylated ß‐carboline, N‐alkylated tetrahydroisoquinolines and their bioisosteres on polysaccharide‐based chiral stationary phases
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- Journal of Separation Science, 2019, v. 42, n. 17, p. 2779, doi. 10.1002/jssc.201900228
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- Article
A Review of Pharmacological Activities of [1,2,4]- Oxadiazoles.
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- International Journal of Pharmaceutical Research (09752366), 2020, p. 1299, doi. 10.31838/ijpr/2020.SP2.121
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- Article
Isocyanide–Based Multicomponent Reactions Coupled One–Pot Process: Efficient Tools to Diversity–Oriented Synthesis of Structural Peptidomimetics.
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- ChemPlusChem, 2024, v. 89, n. 6, p. 1, doi. 10.1002/cplu.202300633
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- Article
Synthesis and biological activity of fused furo[2,3-d]pyrimidinone derivatives as analgesic and antitumor agents.
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- Research on Chemical Intermediates, 2016, v. 42, n. 2, p. 939, doi. 10.1007/s11164-015-2064-8
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- Article
Outstanding effect of the conformational restriction of isoquinolines: hints for the development of optimized antimicrobial agents.
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- Research on Chemical Intermediates, 2013, v. 39, n. 7, p. 2955, doi. 10.1007/s11164-012-0808-2
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- Article
Difluoromethyl Nitrile Oxide (CF<sub>2</sub>HCNO): A Neglected Chemical Reagent.
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- European Journal of Organic Chemistry, 2017, v. 2017, n. 27, p. 3935, doi. 10.1002/ejoc.201700764
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- Article
Synthesis and Biological Evaluation of Migrastatin Macrotriazoles.
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- European Journal of Organic Chemistry, 2017, v. 2017, n. 1, p. 60, doi. 10.1002/ejoc.201600988
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- Article
4′-Selenonucleosides as Next-Generation Nucleosides.
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- European Journal of Organic Chemistry, 2015, v. 2015, n. 28, p. 6115, doi. 10.1002/ejoc.201500429
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- Article
Synthesis of [(1,2,3-Triazol-1-yl)methyl]boronic Acids Through Click Chemistry: Easy Access to a Potential Scaffold for Protease Inhibitors.
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- European Journal of Organic Chemistry, 2015, v. 2015, n. 5, p. 1075, doi. 10.1002/ejoc.201403408
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- Article
Role of Side-Chain Bioisosteres in Determining the Binding Affinity of Click Chemistry Derived RGD Peptidomimetics to α<sub>v</sub>β<sub>3</sub> Integrin.
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- European Journal of Organic Chemistry, 2014, v. 2014, n. 34, p. 7595, doi. 10.1002/ejoc.201403129
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- Article
Probing the Orthosteric Binding Site of GABA Receptors with Heterocyclic GABA Carboxylic Acid Bioisosteres.
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- Neurochemical Research, 2014, v. 39, n. 6, p. 1005, doi. 10.1007/s11064-013-1226-6
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- Article
Divergent Strain‐Release Amino‐Functionalization of [1.1.1]Propellane with Electrophilic Nitrogen‐Radicals.
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- Angewandte Chemie, 2020, v. 132, n. 21, p. 8302, doi. 10.1002/ange.202000140
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- Article
1,3‐Difunctionalizations of [1.1.1]Propellane via 1,2‐Metallate Rearrangements of Boronate Complexes.
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- Angewandte Chemie, 2020, v. 132, n. 10, p. 3945, doi. 10.1002/ange.201914875
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- Article
Synthesis of Sulfonimidamides from Sulfenamides via an Alkoxy‐amino‐λ<sup>6</sup>‐sulfanenitrile Intermediate.
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- Angewandte Chemie, 2019, v. 131, n. 40, p. 14441, doi. 10.1002/ange.201906001
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- Article
Enantioselective, Catalytic Vicinal Difluorination of Alkenes.
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- Angewandte Chemie, 2018, v. 130, n. 50, p. 16669, doi. 10.1002/ange.201810328
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- Article
Diastereocontrolled Monoprotodeboronation of β‐Sulfinimido gem‐Bis(boronates): A General and Stereoselective Route to α,β‐Disubstituted β‐Aminoalkylboronates.
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- Angewandte Chemie, 2018, v. 130, n. 32, p. 10461, doi. 10.1002/ange.201804277
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- Article
Berichtigung: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere.
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- Angewandte Chemie, 2018, v. 130, n. 28, p. 8491, doi. 10.1002/ange.201711161
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- Article
Bioisosteric Exchange of C.
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- Angewandte Chemie, 2016, v. 128, n. 12, p. 4117, doi. 10.1002/ange.201511672
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- Article
Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere.
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- Angewandte Chemie, 2016, v. 128, n. 11, p. 3644, doi. 10.1002/ange.201510675
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- Article
Copper-Catalyzed Asymmetric Synthesis of Tertiary α-Hydroxy Phosphonic Acid Derivatives with In Situ Generated Nitrosocarbonyl Compounds as the Oxygen Source.
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- Angewandte Chemie, 2014, v. 126, n. 52, p. 14700, doi. 10.1002/ange.201408893
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- Article
Simple Sulfinate Synthesis Enables CH Trifluoromethylcyclopropanation.
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- Angewandte Chemie, 2014, v. 126, n. 37, p. 10009, doi. 10.1002/ange.201406622
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- Article
Benzenesulfonamides act as open-channel blockers on K<sub>V</sub>3.1 potassium channel.
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- Amino Acids, 2019, v. 51, n. 2, p. 355, doi. 10.1007/s00726-018-2669-5
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- Article
Deconstruction – Reconstruction: Analysis of the Crucial Structural Elements of GluN2B-Selective, Negative Allosteric NMDA Receptor Modulators with 3-Benzazepine Scaffold.
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- Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2021, v. 55, p. 1, doi. 10.33594/00000033
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- Article
Reaction Paradigms that Leverage Cycloaddition and Ring Strain to Construction Bicyclic Aryl Bioisosteres from Bicyclo[1.1.0]butanes.
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- Asian Journal of Organic Chemistry, 2024, v. 13, n. 5, p. 1, doi. 10.1002/ajoc.202400045
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- Article
Palladium-Catalyzed Fluorination of Cyclic Vinyl Triflates: Effect of TESCF<sub>3</sub> as an Additive.
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- Angewandte Chemie International Edition, 2016, v. 55, n. 50, p. 15559, doi. 10.1002/anie.201608927
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- Article
Bioisosteric Exchange of C.
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- Angewandte Chemie International Edition, 2016, v. 55, n. 12, p. 4049, doi. 10.1002/anie.201511672
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- Publication type:
- Article
Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere.
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- Angewandte Chemie International Edition, 2016, v. 55, n. 11, p. 3580, doi. 10.1002/anie.201510675
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- Article
Frontispiece: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere.
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- Angewandte Chemie International Edition, 2016, v. 55, n. 11, p. n/a, doi. 10.1002/anie.201681161
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- Article
Facile Synthesis and Properties of 2-λ<sup>5</sup>-Phosphaquinolines and 2-λ<sup>5</sup>-Phosphaquinolin-2-ones.
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- Angewandte Chemie International Edition, 2015, v. 54, n. 45, p. 13318, doi. 10.1002/anie.201507696
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- Article
Simple Sulfinate Synthesis Enables CH Trifluoromethylcyclopropanation.
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- Angewandte Chemie International Edition, 2014, v. 53, n. 37, p. 9851, doi. 10.1002/anie.201406622
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- Article
Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors.
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- Canadian Journal of Chemistry, 2016, v. 94, n. 3, p. 240, doi. 10.1139/cjc-2015-0475
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- Article
Functionalization of Cubane Formation of C−C and C−Heteroatom Bonds.
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- Helvetica Chimica Acta, 2024, v. 107, n. 2, p. 1, doi. 10.1002/hlca.202300200
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- Article
Design, synthesis, and biological evaluation of triazole-pyrimidine-methylbenzonitrile derivatives as dual A<sub>2A</sub>/A<sub>2B</sub> adenosine receptor antagonists.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 1514, doi. 10.1080/14756366.2022.2077731
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- Article
1-(5-Carboxyindazol-1-yl)propan-2-ones as dual inhibitors of cytosolic phospholipase A 2 α and fatty acid amide hydrolase: bioisosteric replacement of the carboxylic acid moiety.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, p. 131, doi. 10.1080/14756366.2016.1178246
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- Article
Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, n. 1, p. 121, doi. 10.3109/14756366.2015.1005012
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- Article
Input of Isosteric and Bioisosteric Approach in Drug Design.
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- Journal of the Chemical Society of Pakistan, 2014, v. 36, n. 1, p. 150
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- Article
Cover Feature: Facile Conversion of Molecularly Complex (Hetero)aryl Carboxylic Acids into Alkynes for Accelerated SAR Exploration (Chem. Eur. J. 60/2021).
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- Chemistry - A European Journal, 2021, v. 27, n. 60, p. 14786, doi. 10.1002/chem.202103635
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- Article