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- Title
An Organophosphorescence Probe with Ultralong Lifetime and Intrinsic Tissue Selectivity for Specific Tumor Imaging and Guided Tumor Surgery.
- Authors
Gao, Heqi; Zhang, Tingting; Lei, Yunxiang; Jiao, Di; Yu, Bo; Yuan, Wang Zhang; Ji, Jian; Jin, Qiao; Ding, Dan
- Abstract
Organic phosphorescent materials are excellent candidates for use in tumor imaging. However, a systematic comparison of the effects of the intensity, lifetime, and wavelength of phosphorescent emissions on bioimaging performance has not yet been undertaken. In addition, there have been few reports on organic phosphorescent materials that specifically distinguish tumors from normal tissues. This study addresses these gaps and reveals that longer lifetimes effectively increase the signal intensity, whereas longer wavelengths enhance the penetration depth. Conversely, a strong emission intensity with a short lifetime does not necessarily yield robust imaging signals. Building upon these findings, an organo‐phosphorescent material with a lifetime of 0.94 s was designed for tumor imaging. Remarkably, the phosphorescent signals of various organic nanoparticles are nearly extinguished in blood‐rich organs because of the quenching effect of iron ions. Moreover, for the first time, we demonstrated that iron ions universally quench the phosphorescence of organic room‐temperature phosphorescent materials, which is an inherent property of such substances. Leveraging this property, both the normal liver and hepatitis tissues exhibit negligible phosphorescent signals, whereas liver tumors display intense phosphorescence. Therefore, phosphorescent materials, unlike chemiluminescent or fluorescent materials, can exploit this unique inherent property to selectively distinguish liver tumor tissues from normal tissues without additional modifications or treatments.
- Subjects
LIVER tumors; COMPUTER-assisted surgery; IRON ions; TUMOR surgery; CARBAZOLE; PHOSPHORESCENCE
- Publication
Angewandte Chemie, 2024, Vol 136, Issue 42, p1
- ISSN
0044-8249
- Publication type
Academic Journal
- DOI
10.1002/ange.202406651