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- Title
2‐Oxabicyclo[2.1.1]hexanes: Synthesis, Properties, and Validation as Bioisosteres of ortho‐ and meta‐Benzenes.
- Authors
Levterov, Vadym V.; Panasiuk, Yaroslav; Shablykin, Oleh; Stashkevych, Oleksandr; Sahun, Kateryna; Rassokhin, Artur; Sadkova, Iryna; Lesyk, Dmytro; Anisiforova, Anna; Holota, Yuliia; Borysko, Petro; Bodenchuk, Iryna; Voloshchuk, Nataliya M.; Mykhailiuk, Pavel K.
- Abstract
We have developed a general and practical approach towards 2‐oxabicyclo[2.1.1]hexanes with two and three exit vectors via an iodocyclization reaction. The obtained compounds have been easily converted into the corresponding building blocks for use in medicinal chemistry. 2‐Oxabicyclo[2.1.1]hexanes have been incorporated into the structure of five drugs and three agrochemicals, and validated biologically as bioisosteres of ortho‐ and meta‐benzenes.
- Subjects
BIOISOSTERES; HEXANE; PHARMACEUTICAL chemistry; RING formation (Chemistry)
- Publication
Angewandte Chemie, 2024, Vol 136, Issue 19, p1
- ISSN
0044-8249
- Publication type
Academic Journal
- DOI
10.1002/ange.202319831