Cellular Metabolism, Enzyme Catalysis, High-Throughput Screening, Microfluidics, Single-Cell Analysis Keywords: Cellular Metabolism; Enzyme Catalysis; High-Throughput Screening; Microfluidics; Single-Cell Analysis EN Cellular Metabolism Enzyme Catalysis High-Throughput Screening Microfluidics Single-Cell Analysis 1 1 1 08/01/23 20230801 NES 230801 B Single-cell analysis b is an effective method to reveal cell heterogeneity. In their Research Article (e202302000), Yujun Song et al. report an enzyme-loaded metal-organic framework-integrated microfluidic chip for highly efficient single-cell capture followed by real-time single-cell metabolite monitoring and analysis.