We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Regio‐ and Chemoselective Formal (4 1) Carbocyclization of Chalcones with Internal Alkynes via Rhodium(III) Catalysis.
- Authors
Song, Shuaishuai; Lai, Yunfei; Tuo, Zekun; Zhong, Jianming; Zhou, Wang
- Abstract
A rhodium(III)‐catalyzed oxidative cyclization of chalcones with internal alkynes is reported, generating biologically important 3,3‐disubstituted 1‐indanones along with reusable aromatic aldehydes. This transformation features unique (4 1) reaction mode, excellent regioselectivity in alkyne insertion, broad substrate scope, allows for the construction of quaternary carbon centers, and is scalable. Steric hindrance from substrate and ligand probably controls the chemoselectivity of this carbocyclization. Importantly, this discovery enables a practical two‐step protocol switching the overall reaction of acetophenones with internal alkynes from a (3 2) to a (4 1) annulation.
- Subjects
RING formation (Chemistry); CHALCONES; RHODIUM; STERIC hindrance; ALKYNES; CHALCONE; AROMATIC aldehydes
- Publication
Angewandte Chemie, 2023, Vol 135, Issue 30, p1
- ISSN
0044-8249
- Publication type
Academic Journal
- DOI
10.1002/ange.202305983