We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Gold‐Catalyzed Amine Cascade Addition to Diyne‐Ene: Enantioselective Synthesis of 1,2‐Dihydropyridines.
- Authors
Wei, Jingwen; Xing, Yangyang; Ye, Xiaohan; Nguyen, Bao; Wojtas, Lukasz; Hong, Xin; Shi, Xiaodong
- Abstract
With the well‐documented chemical and biological applications, piperidine and pyridine are among the most important N‐heterocycles, and a new synthetic strategy, especially one with an alternative bond‐forming design, is of general interest. Using the gold‐catalyzed intermolecular condensation of amine and diyne‐ene, we report herein the first example of enantioselective 1,2‐dihydropyridine synthesis through a formal [3+2+1] fashion (up to 95 % yield, up to 99 % e.e.).
- Subjects
AMINES; PIPERIDINE; PYRIDINE; CONDENSATION; DIHYDROPYRIDINE
- Publication
Angewandte Chemie, 2023, Vol 135, Issue 31, p1
- ISSN
0044-8249
- Publication type
Academic Journal
- DOI
10.1002/ange.202305409