Results
Title

Activatable Persistent Luminescence from Porphyrin Derivatives and Supramolecular Probes with Imaging‐Modality Transformable Characteristics for Improved Biological Applications**.

Authors

Duan, Xingchen; Zhang, Guo‐Qiang; Ji, Shenglu; Zhang, Yiming; Li, Jun; Ou, Hanlin; Gao, Zhiyuan; Feng, Guangxue; Ding, Dan

Abstract

Persistent luminescence without excitation light and tissue autofluorescence interference holds great promise for biological applications, but is limited by available materials with long‐wavelength emission and excellent clinical potential. Here, we report that porphyrin derivatives can emit near‐infrared persistent luminescence over 60 min after cessation of excitation light or on interaction with peroxynitrite. A plausible mechanism of the successive oxidation of vinylene bonds was demonstrated. A supramolecular probe with a β‐sheet structure was constructed to enhance the tumor targeting ability and the photoacoustic and persistent luminescence signals. Such probes featuring light‐triggered function transformation from photoacoustic imaging to persistent luminescence imaging permit advanced image‐guided cancer surgery. Furthermore, peroxynitrite‐activated persistent luminescence of the supramolecular probe also enables rapid and precise screening of immunogenic cell death drugs.

Subjects

LUMINESCENCE; PORPHYRINS; ACOUSTIC imaging; COMPUTER-assisted surgery; ONCOLOGIC surgery; BIOFLUORESCENCE; PHOTOACOUSTIC spectroscopy; METALLOPORPHYRINS

Publication

Angewandte Chemie, 2022, Vol 134, Issue 24, p1

ISSN

0044-8249

Publication type

Academic Journal

DOI

10.1002/ange.202116174