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- Title
Hemicyanine‐Based Near‐Infrared Activatable Probes for Imaging and Diagnosis of Diseases.
- Authors
Zeng, Ziling; Liew, Si Si; Wei, Xin; Pu, Kanyi
- Abstract
Molecular activatable probes with near‐infrared (NIR) fluorescence play a critical role in in vivo imaging of biomarkers for drug screening and disease diagnosis. With structural diversity and high fluorescence quantum yields, hemicyanine dyes have emerged as a versatile scaffold for the construction of activatable optical probes. This Review presents a survey of hemicyanine‐based NIR activatable probes (HNAPs) for in vivo imaging and early diagnosis of diseases. The molecular design principles of HNAPs towards activatable optical signaling against various biomarkers are discussed with a focus on their broad applications in the detection of diseases including inflammation, acute organ failure, skin diseases, intestinal diseases, and cancer. This progress not only proves the unique value of HNAPs in preclinical research but also highlights their high translational potential in clinical diagnosis.
- Subjects
DIAGNOSIS; FLUORESCENCE yield; MOLECULAR probes; INTESTINAL diseases
- Publication
Angewandte Chemie, 2021, Vol 133, Issue 51, p26658
- ISSN
0044-8249
- Publication type
Academic Journal
- DOI
10.1002/ange.202107877