Hemicyanine‐Based Near‐Infrared Activatable Probes for Imaging and Diagnosis of Diseases.

Zeng, Ziling; Liew, Si Si; Wei, Xin; Pu, Kanyi

Molecular activatable probes with near‐infrared (NIR) fluorescence play a critical role in in vivo imaging of biomarkers for drug screening and disease diagnosis. With structural diversity and high fluorescence quantum yields, hemicyanine dyes have emerged as a versatile scaffold for the construction of activatable optical probes. This Review presents a survey of hemicyanine‐based NIR activatable probes (HNAPs) for in vivo imaging and early diagnosis of diseases. The molecular design principles of HNAPs towards activatable optical signaling against various biomarkers are discussed with a focus on their broad applications in the detection of diseases including inflammation, acute organ failure, skin diseases, intestinal diseases, and cancer. This progress not only proves the unique value of HNAPs in preclinical research but also highlights their high translational potential in clinical diagnosis.

DIAGNOSIS; FLUORESCENCE yield; MOLECULAR probes; INTESTINAL diseases

Angewandte Chemie, 2021, Vol 133, Issue 51, p26658

0044-8249

Academic Journal

10.1002/ange.202107877