Multicomponent Self‐Assembly of a Giant Heterometallic Polyoxotungstate Supercluster with Antitumor Activity.

Liu, Jian‐Cai; Wang, Jie‐Fei; Han, Qing; Shangguan, Ping; Liu, Lu‐Lu; Chen, Li‐Juan; Zhao, Jun‐Wei; Streb, Carsten; Song, Yu‐Fei

The hierarchical aggregation of molecular nanostructures from multiple components is a grand synthetic challenge, which requires highly selective linkage control. We demonstrate how two orthogonal linkage groups, that is, organotin and lanthanide cations, can be used to drive the aggregation of a giant molecular metal oxide superstructure. The title compound {[(Sn(CH3)2)2O]4{[CeW5O18] [TeW4O16][CeSn(CH3)2]4[TeW8O31]4}2}46− (1 a) features dimensions of ca. 2.2×2.3×3.4 nm3 and a molecular weight of ca. 25 kDa. Structural analysis shows the hierarchical aggregation from several independent subunits. Initial biomedical tests show that 1 features an inhibitory effect on the proliferation of HeLa cells based on an apoptosis pathway. In vivo experiments in mice reveal the antiproliferative activity of 1 and open new paths for further development of this new compound class.

ORGANIC conductors; HELA cells; METALLIC oxides; CELL proliferation; MOLECULAR weights

Angewandte Chemie, 2021, Vol 133, Issue 20, p11253

0044-8249

Academic Journal

10.1002/ange.202017318