Results
Title

The Total Synthesis of Chondrochloren A.

Authors

Linne, Yannick; Bonandi, Elisa; Tabet, Christopher; Geldsetzer, Jan; Kalesse, Markus

Abstract

The first total synthesis of chondrochloren A is accomplished using a 1,2‐metallate rearrangement addition as an alternative for the Nozaki‐Hiyama‐Kishi reaction. This transformation also avoids the inherent challenges of this polyketide segment and provides a new, unprecedented strategy to assemble polyketidal frameworks. The formation of the Z‐enamide is accomplished using a Z‐selective cross coupling of the corresponding amide to a Z‐vinyl bromide.

Subjects

POLYKETIDES; NATURAL products; BROMIDES

Publication

Angewandte Chemie, 2021, Vol 133, Issue 13, p7014

ISSN

0044-8249

Publication type

Academic Journal

DOI

10.1002/ange.202016072