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- Title
The Total Synthesis of Chondrochloren A.
- Authors
Linne, Yannick; Bonandi, Elisa; Tabet, Christopher; Geldsetzer, Jan; Kalesse, Markus
- Abstract
The first total synthesis of chondrochloren A is accomplished using a 1,2‐metallate rearrangement addition as an alternative for the Nozaki‐Hiyama‐Kishi reaction. This transformation also avoids the inherent challenges of this polyketide segment and provides a new, unprecedented strategy to assemble polyketidal frameworks. The formation of the Z‐enamide is accomplished using a Z‐selective cross coupling of the corresponding amide to a Z‐vinyl bromide.
- Subjects
POLYKETIDES; NATURAL products; BROMIDES
- Publication
Angewandte Chemie, 2021, Vol 133, Issue 13, p7014
- ISSN
0044-8249
- Publication type
Academic Journal
- DOI
10.1002/ange.202016072