Dried Blood Spot Self‐Sampling with Automated Capillary Electrophoresis Processing for Clinical Analysis.

Ryšavá, Lenka; Dvořák, Miloš; Kubáň, Pavel

A simple and convenient concept of blood sampling followed by a fully automated analysis is presented. A disposable sampling kit is used for accurate self‐sampling of capillary blood from a finger prick. A high‐throughput blood sampling is thus enabled, which is essential in many clinical assays and considerably improves life quality and comfort of involved subjects. The collected blood samples are mailed to a laboratory for a fully automated dried blood spot (DBS) processing and analysis, which are performed with a commercial capillary electrophoresis instrument. Quantitative results are obtained within 20 min from the DBS delivery to the laboratory. The presented concept is exemplified by the determination of warfarin blood concentrations and demonstrates excellent analytical performance. Moreover, this concept is generally applicable to a wide range of endogenous and exogenous blood compounds and represents a novel and attractive analytical tool for personalized health monitoring.

CAPILLARY electrophoresis; BLOOD sampling; QUALITY of life; WARFARIN

Angewandte Chemie, 2021, Vol 133, Issue 11, p6133

0044-8249

Academic Journal

10.1002/ange.202012997