Title: Nickel‐Catalyzed, Regio‐ and Enantioselective Benzylic Alkenylation of Olefins with Alkenyl Bromide.
Authors: Liu, Jiandong; Gong, Hegui; Zhu, Shaolin
Abstract: A NiH‐catalyzed migratory hydroalkenylation reaction of olefins with alkenyl bromides has been developed, affording benzylic alkenylation products with high yields and excellent chemoselectivity. The mild conditions of the reaction preclude olefinic products from undergoing further isomerization or subsequent alkenylation. Catalytic enantioselective hydroalkenylation of styrenes was achieved by using a chiral bisoxazoline ligand.
Subjects: ALKENYLATION; ALKENES; BROMIDES; ISOMERIZATION; STYRENE; ALKENYL group; CHEMOSELECTIVITY; ENANTIOSELECTIVE catalysis
Publication: Angewandte Chemie, 2021, Vol 133, Issue 8, p4106
ISSN: 0044-8249
Publication type: Academic Journal
DOI: 10.1002/ange.202012614

Nickel‐Catalyzed, Regio‐ and Enantioselective Benzylic Alkenylation of Olefins with Alkenyl Bromide.

Liu, Jiandong; Gong, Hegui; Zhu, Shaolin