Palladium‐Catalyzed Electrophilic Functionalization of Pyridine Derivatives through Phosphonium Salts.

Che, Yuan‐Yuan; Yue, Yanni; Lin, Ling‐Zhi; Pei, Bingbing; Deng, Xuezu; Feng, Chao

Herein, we report a highly efficient and practical method for pyridine‐derived heterobiaryl synthesis through palladium‐catalyzed electrophilic functionalization of easily available pyridine‐derived quaternary phosphonium salts. The nice generality of this reaction was goes beyond arylation, enabling facile incorporation of diverse carbon‐based fragments, including alkenyl, alkynyl, and also allyl fragments, onto the pyridine core. Notably, the silver salt additive is revealed to be of vital importance for the success of this transformation and its pivotal role as transmetallation mediator, which guarantees a smooth transfer of pyridyl group to palladium intermediate, is also described.

PHOSPHONIUM compounds; PYRIDINE derivatives; SILVER salts; PALLADIUM; ARYLATION

Angewandte Chemie, 2020, Vol 132, Issue 38, p16556

0044-8249

Academic Journal

10.1002/ange.202006724