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- Title
Saturated Bioisosteres of ortho‐Substituted Benzenes.
- Authors
Denisenko, Aleksandr; Garbuz, Pavel; Shishkina, Svetlana V.; Voloshchuk, Nataliya M.; Mykhailiuk, Pavel K.
- Abstract
Saturated bioisosteres of ortho‐disubstituted benzenes (bicyclo[2.1.1]hexanes) were synthesized, characterized and validated. These cores were incorporated into the bioactive compounds Valsartan, Boskalid and Fluxapyroxad instead of the benzene ring. The saturated analogues showed a similar level of antifungal activity compared to that of Boskalid and Fluxapyroxad.
- Subjects
BIOISOSTERES; BENZENE; BIOACTIVE compounds; VALSARTAN; HEXANE; BENZENE derivatives
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 46, p20696
- ISSN
0044-8249
- Publication type
Academic Journal
- DOI
10.1002/ange.202004183