Title: Saturated Bioisosteres of ortho‐Substituted Benzenes.
Authors: Denisenko, Aleksandr; Garbuz, Pavel; Shishkina, Svetlana V.; Voloshchuk, Nataliya M.; Mykhailiuk, Pavel K.
Abstract: Saturated bioisosteres of ortho‐disubstituted benzenes (bicyclo[2.1.1]hexanes) were synthesized, characterized and validated. These cores were incorporated into the bioactive compounds Valsartan, Boskalid and Fluxapyroxad instead of the benzene ring. The saturated analogues showed a similar level of antifungal activity compared to that of Boskalid and Fluxapyroxad.
Subjects: BIOISOSTERES; BENZENE; BIOACTIVE compounds; VALSARTAN; HEXANE; BENZENE derivatives
Publication: Angewandte Chemie, 2020, Vol 132, Issue 46, p20696
ISSN: 0044-8249
Publication type: Academic Journal
DOI: 10.1002/ange.202004183

Saturated Bioisosteres of ortho‐Substituted Benzenes.

Denisenko, Aleksandr; Garbuz, Pavel; Shishkina, Svetlana V.; Voloshchuk, Nataliya M.; Mykhailiuk, Pavel K.