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- Title
Calixarene‐Based Supramolecular AIE Dots with Highly Inhibited Nonradiative Decay and Intersystem Crossing for Ultrasensitive Fluorescence Image‐Guided Cancer Surgery.
- Authors
Chen, Chao; Ni, Xiang; Tian, Han‐Wen; Liu, Qian; Guo, Dong‐Sheng; Ding, Dan
- Abstract
Host–guest complexation between calix[5]arene and aggregation‐induced emission luminogen (AIEgen) can significantly turn off both the energy dissipation pathways of intersystem crossing and thermal deactivation, enabling the absorbed excitation energy to mostly focus on fluorescence emission. The co‐assembly of calix[5]arene amphiphiles and AIEgens affords highly emissive supramolecular AIE nanodots thanks to their interaction severely restricting the intramolecular motion of AIEgens, which also show negligible generation of cytotoxic reactive oxygen species. In vivo studies with a peritoneal carcinomatosis‐bearing mouse model indicate that such supramolecular AIE dots have rather low in vivo side toxicity and can serve as a superior fluorescent bioprobe for ultrasensitive fluorescence image‐guided cancer surgery.
- Subjects
COMPUTER-assisted surgery; ONCOLOGIC surgery; FLUORESCENCE; ENERGY dissipation; BIO-imaging sensors; REACTIVE oxygen species
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 25, p10094
- ISSN
0044-8249
- Publication type
Academic Journal
- DOI
10.1002/ange.201916430