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- Title
Paper‐Based Ratiometric Fluorescence Analytical Devices towards Point‐of‐Care Testing of Human Serum Albumin.
- Authors
Luo, Zijie; Lv, Taoyuze; Zhu, Kangning; Li, Yi; Wang, Lei; Gooding, J. Justin; Liu, Guozhen; Liu, Bin
- Abstract
Monitoring of human serum albumin (HSA) in a point‐of‐care fashion is urgently needed in particular for elderly or chronically ill patients. Herein, a dual‐state emissive chalcone probe having the feature of aggregation‐induced emission was designed and synthesized. The concentration of HSA can be evaluated by the ratios of emission from probes in aggregated and monomeric state, which gives a visually discernible red‐to‐green color change. A simple, portable paper‐based analytical device have been fabricated by integration of the recognition probe in the detection pad and employed for HSA test using the whole blood samples. This paper‐based assay shows the analytical capability comparable to the standard testing methods but is in a point‐of‐care fashion, providing a promising tool for at‐home HSA detection and HSA‐related disease diagnosis.
- Subjects
POINT-of-care testing; SERUM albumin; FLUORESCENCE; CHRONICALLY ill; BLOOD sampling; DIAGNOSIS
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 8, p3155
- ISSN
0044-8249
- Publication type
Academic Journal
- DOI
10.1002/ange.201915046