We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Amphiphilic Polyphenylene Dendron Conjugates for Surface Remodeling of Adenovirus 5.
- Authors
Wagner, Jessica; Li, Longjie; Simon, Johanna; Krutzke, Lea; Landfester, Katharina; Mailänder, Volker; Müllen, Klaus; Ng, David Y. W.; Wu, Yuzhou; Weil, Tanja
- Abstract
Amphiphilic surface groups play an important role in many biological processes. The synthesis of amphiphilic polyphenylene dendrimer branches (dendrons), providing alternating hydrophilic and lipophilic surface groups and one reactive ethynyl group at the core is reported. The amphiphilic surface groups serve as biorecognition units that bind to the surface of adenovirus 5 (Ad5), which is a common vector in gene therapy. The Ad5/dendron complexes showed high gene transduction efficiencies in coxsackie‐adenovirus receptor (CAR)‐negative cells. Moreover, the dendrons offer incorporation of new functions at the dendron core by in situ post‐modifications, even when bound to the Ad5 surface. Surfaces coated with these dendrons were analyzed for their blood‐protein binding capacity, which is essential to predict their performance in the blood stream. A new platform for introducing bioactive groups to the Ad5 surface without chemically modifying the virus particles is provided.
- Subjects
HYDROPHOBIC surfaces; ADENOVIRUSES; HYDROPHILIC surfaces; GENE therapy; SURFACE coatings; POLYMERSOMES; POLYAMIDOAMINE dendrimers
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 14, p5761
- ISSN
0044-8249
- Publication type
Academic Journal
- DOI
10.1002/ange.201913708