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- Title
Yttrium‐86 Is a Positron Emitting Surrogate of Gadolinium for Noninvasive Quantification of Whole‐Body Distribution of Gadolinium‐Based Contrast Agents.
- Authors
Le Fur, Mariane; Rotile, Nicholas J.; Correcher, Carlos; Clavijo Jordan, Veronica; Ross, Alana W.; Catana, Ciprian; Caravan, Peter
- Abstract
Gadolinium‐based contrast agents (GBCAs) are used to provide diagnostic information in clinical magnetic resonance (MR) examinations. Gadolinium (Gd) has been detected in the brain, bone and skin of patients, months and years following GBCA administration, raising concerns about long term toxicity. Despite increased scrutiny, the concentration, chemical form and fate of the retained gadolinium species remain unknown. Importantly, the whole body biodistribution and organ clearance of GBCAs is poorly understood in humans. Gadolinium lacks suitable isotopes for nuclear imaging. We demonstrate that the yttrium‐86 isotope can be used as a gadolinium surrogate. We show that Gd and their analogous Y complexes have similar properties both in solution and in vivo, and that yttrium‐86 PET can be used to track the biodistribution of GBCAs over a two‐day period.
- Subjects
GADOLINIUM; POSITRONS; ORGANS (Anatomy); MAGNETIC resonance
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 4, p1490
- ISSN
0044-8249
- Publication type
Academic Journal
- DOI
10.1002/ange.201911858