Chirality‐Driven Transportation and Oxidation Prevention by Chiral Selenium Nanoparticles.

Huang, Yanyu; Fu, Yuanting; Li, Mengting; Jiang, Dawei; Kutyreff, Christopher J.; Engle, Jonathan W.; Lan, Xiaoli; Cai, Weibo; Chen, Tianfeng

The chirality of nanoparticles directly influences their transport and biological effects under physiological conditions, but the details of this phenomenon have rarely been explored. Herein, chiral GSH‐anchored selenium nanoparticles (G@SeNPs) are fabricated to investigate the effect of their chirality on their transport and antioxidant activity. G@SeNPs modified with different enantiomers show opposite handedness with a tunable circular dichroism signal. Noninvasive positron emission tomography imaging clearly reveals that 64Cu‐labeled l‐G@SeNPs experience distinctly different transport among the major organs from that of their d‐and dl‐counterparts, demonstrating that the chirality of the G@SeNPs influences the biodistribution and kinetics. Taking advantage of the strong homologous cell adhesion and uptake, l‐G@SeNPs have been shown here to effectively prevent oxidation damage caused by palmitic acid in insulinoma cells.

BIOLOGICAL transport; SELENIUM; POSITRON emission tomography; NANOPARTICLES; PALMITIC acid

Angewandte Chemie, 2020, Vol 132, Issue 11, p4436

0044-8249

Academic Journal

10.1002/ange.201910615