Results
Title

Nickel‐Catalyzed Conversion of Enol Triflates into Alkenyl Halides.

Authors

Hofstra, Julie L.; Poremba, Kelsey E.; Shimozono, Alex M.; Reisman, Sarah E.

Abstract

A Ni‐catalyzed halogenation of enol triflates was developed and it enables the synthesis of a broad range of alkenyl iodides, bromides, and chlorides under mild reaction conditions. The reaction utilizes inexpensive, bench‐stable Ni(OAc)2⋅4 H2O as a precatalyst and proceeds at room temperature in the presence of sub‐stoichiometric Zn and either 1,5‐cyclooctadiene or 4‐(N,N‐dimethylamino)pyridine.

Subjects

HALIDES; IODIDES; HALOGENATION; BROMIDES; WATER; ALKENYL group; ARYL iodides

Publication

Angewandte Chemie, 2019, Vol 131, Issue 42, p15043

ISSN

0044-8249

Publication type

Academic Journal

DOI

10.1002/ange.201906815