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- Title
Hyperpolarising Pyruvate through Signal Amplification by Reversible Exchange (SABRE).
- Authors
Iali, Wissam; Roy, Soumya S.; Tickner, Ben J.; Ahwal, Fadi; Kennerley, Aneurin J.; Duckett, Simon B.
- Abstract
Hyperpolarisation methods that premagnetise agents such as pyruvate are currently receiving significant attention because they produce sensitivity gains that allow disease tracking and interrogation of cellular metabolism by magnetic resonance. Here, we communicate how signal amplification by reversible exchange (SABRE) can provide strong 13C pyruvate signal enhancements in seconds through the formation of the novel polarisation transfer catalyst [Ir(H)2(η2‐pyruvate)(DMSO)(IMes)]. By harnessing SABRE, strong signals for [1‐13C]‐ and [2‐13C]pyruvate in addition to a long‐lived singlet state in the [1,2‐13C2] form are readily created; the latter can be observed five minutes after the initial hyperpolarisation step. We also demonstrate how this development may help with future studies of chemical reactivity.
- Subjects
PYRUVATES; MAGNETIC resonance; EXCHANGE; QUESTIONING
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 30, p10377
- ISSN
0044-8249
- Publication type
Academic Journal
- DOI
10.1002/ange.201905483