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- Title
Coordinatively Unsaturated Fe<sup>3 </sup> Based Activatable Probes for Enhanced MRI and Therapy of Tumors.
- Authors
Zhang, Peisen; Hou, Yi; Zeng, Jianfeng; Li, Yingying; Wang, Zihua; Zhu, Ran; Ma, Tiancong; Gao, Mingyuan
- Abstract
Exogenous FeIII can be used for cancer magnetic resonance (MR) imaging and potentially for cancer treatment by a ferroptosis pathway or photothermal ablation. To achieve this, effective and accurate delivery of FeIII to cancerous sites is critical, requiring a balance of release kinetics of Fe3 in tumorous and normal tissues. A nanoprobe is described consisting of upconversion luminescence (UCL) nanoparticles as a core and a coordinatively unsaturated FeIII‐containing Fe3 /gallic acid complex as a shell. Owing to the introduction of an unsaturated coordination structure, FeIII in the nanoprobe can be released only in the tumor microenvironment in response to the lightly acidic pH. The multiple UCLs are used for quantitatively visualizing the release of Fe3 in vivo, whilst the release resultant serves as a photothermal agent. This nanoprobe exhibited ligand‐free tumor targeting ability, activatable MR imaging performance, and efficacious therapeutic effects against tumors in vivo.
- Subjects
MAGNETIC resonance imaging; TUMORS; MAGNETIC resonance; TUMOR microenvironment; IMAGING of cancer; LUMINESCENCE
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 32, p11205
- ISSN
0044-8249
- Publication type
Academic Journal
- DOI
10.1002/ange.201904880