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- Title
Ion‐Mobility Mass Spectrometry for the Rapid Determination of the Topology of Interlocked and Knotted Molecules.
- Authors
Kruve, Anneli; Caprice, Kenji; Lavendomme, Roy; Wollschläger, Jan M.; Schoder, Stefan; Schröder, Hendrik V.; Nitschke, Jonathan R.; Cougnon, Fabien B. L.; Schalley, Christoph A.
- Abstract
A rapid screening method based on traveling‐wave ion‐mobility spectrometry (TWIMS) combined with tandem mass spectrometry provides insight into the topology of interlocked and knotted molecules, even when they exist in complex mixtures, such as interconverting dynamic combinatorial libraries. A TWIMS characterization of structure‐indicative fragments generated by collision‐induced dissociation (CID) together with a floppiness parameter defined based on parent‐ and fragment‐ion arrival times provide a straightforward topology identification. To demonstrate its broad applicability, this approach is applied here to six Hopf and two Solomon links, a trefoil knot, and a [3]catenate.
- Subjects
MASS spectrometry; TOPOLOGY; MOLECULES
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 33, p11446
- ISSN
0044-8249
- Publication type
Academic Journal
- DOI
10.1002/ange.201904541