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- Title
A Platinum(II) Complex of Heptamethine Cyanine for Photoenhanced Cytotoxicity and Cellular Imaging in Near‐IR Light.
- Authors
Mitra, Koushambi; Lyons, Charles E.; Hartman, Matthew C. T.
- Abstract
Abstract: Controlled generation of cytotoxic agents with near‐IR light is a current focus of photoactivated cancer therapy, including that involving cytotoxic platinum species. A heptamethine cyanine scaffolded PtII complex, IR797‐Platin exhibits unprecedented Pt−O bond scission and enhancement in DNA platination in near‐IR light. This complex also displayed significant singlet oxygen quantum yield thereby qualifying as a near‐IR photodynamic therapeutic agent. The complex showed 30–60 fold enhancement of cytotoxicity in near‐IR light in various cancer cell lines. The cellular imaging properties were also leveraged to observe its significant co‐localization in cytoplasmic organelles. This is the first demonstration of a near‐IR light‐initiated therapy involving the cytotoxic effects of both active cisplatin and singlet oxygen.
- Subjects
CYANINES; FOURIER transform infrared spectroscopy; HIGH performance liquid chromatography; PLATINUM; PHOTODYNAMIC therapy
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 32, p10420
- ISSN
0044-8249
- Publication type
Academic Journal
- DOI
10.1002/ange.201806911