Results
Title

Self‐Propelled Nanomotors for Thermomechanically Percolating Cell Membranes.

Authors

Xuan, Mingjun; Shao, Jingxin; Gao, Changyong; Wang, Wei; Dai, Luru; He, Qiang

Abstract

Abstract: We report a near‐infrared (NIR) light‐powered Janus mesoporous silica nanomotor (JMSNM) with macrophage cell membrane (MPCM) cloaking that can actively seek cancer cells and thermomechanically percolate cell membrane. Upon exposure to NIR light, a heat gradient across the Janus boundary of the JMSNMs is generated by the photothermal effect of the Au half‐shells, resulting in a self‐thermophoretic force that propels the JMSNMs. In biological medium, the MPCM camouflaging can not only prevent dissociative biological blocks from adhering to JMSNMs but also improve the seeking sensitivity of the nanomotors by specifically recognizing cancer cells. The biofriendly propulsion and recognition capability enable JMSNMs to achieve the active seeking and bind to the membrane of cancer cells. Subsequent illumination with NIR then triggers the photothermal effect of MPCM@JMSNMs to thermomechanically perforate the cytomembranes for guest molecular injection. This approach integrates the functions of active seeking, cytomembranes perforating, and thermomechanical therapy in nanomotors, which may pave the way to apply self‐propelled motors in biomedical fields.

Subjects

CANCER cells; NANOMOTORS; MACROPHAGES; CELL membranes; NANOSTRUCTURED materials

Publication

Angewandte Chemie, 2018, Vol 130, Issue 38, p12643

ISSN

0044-8249

Publication type

Academic Journal

DOI

10.1002/ange.201806759