Title: Palladium-Catalyzed Fluoroarylation of gem-Difluoroalkenes.
Authors: Tang, Hai ‐ Jun; Lin, Ling ‐ Zhi; Feng, Chao; Loh, Teck ‐ Peng
Abstract: A Pd-catalyzed fluoroarylation of gem-difluoroalkenes with aryl halides is reported. By taking advantage of the in situ generated α-CF3-benzylsilver intermediates derived from the nucleophilic addition of silver fluoride to gem-difluoroalkenes, this strategy bypasses the use of a strong base, thus enabling a mild and general synthetic method for ready access to non-symmetric α,α-disubstituted trifluoroethane derivatives.
Subjects: PALLADIUM catalysts; ARYLATION; ALKENES; INTERMEDIATES (Chemistry); ARYL halides; NUCLEOPHILIC addition (Chemistry)
Publication: Angewandte Chemie, 2017, Vol 129, Issue 33, p10004
ISSN: 0044-8249
Publication type: Academic Journal
DOI: 10.1002/ange.201705321

Palladium-Catalyzed Fluoroarylation of gem-Difluoroalkenes.

Tang, Hai ‐ Jun; Lin, Ling ‐ Zhi; Feng, Chao; Loh, Teck ‐ Peng