We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The cis-Diammineplatinum (II) Complex of Curcumin: A Dual Action DNA Crosslinking and Photochemotherapeutic Agent.
- Authors
Mitra, Koushambi; Gautam, Srishti; Kondaiah, Paturu; Chakravarty, Akhil R.
- Abstract
[Pt(cur)(NH3)2](NO3) (1), a curcumin-bound cisdiammineplatinum (II) complex, nicknamed Platicur, as a novel photoactivated chemotherapeutic agent releases photoactive curcumin and an active platinum(II) species upon irradiation with visible light. The hydrolytic instability of free curcumin reduces upon binding to platinum(II). Interactions of 1 with 5'-GMP and ct-DNA indicated formation of platinum-bound DNA adducts upon exposure to visible light (λ=400-700 nm). It showed apoptotic photocytotoxicity in cancer cells (IC50≈15 µm), thus forming ·OH, while remaining passive in the darkness (IC50>200 mm). A comet assay and platinum estimation suggest Pt-DNA crosslink formation. The fluorescence microscopic images showed cytosolic localization of curcumin, thus implying possibility of dual action as a chemo- and phototherapeutic agent.
- Subjects
CURCUMIN; PLATINUM compound synthesis; CROSSLINKING (Polymerization); PHOTOCHEMOTHERAPY; CHEMICAL adducts; CELL imaging
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 47, p14195
- ISSN
0044-8249
- Publication type
Academic Journal
- DOI
10.1002/ange.201507281