Title: Design, Synthesis, and Application of a Trifluoromethylated Phenylalanine Analogue as a Label to Study Peptides by Solid-State <sup>19</sup>F NMR Spectroscopy.
Authors: Tkachenko, Anton N.; Radchenko, Dmytro S.; Mykhailiuk, Pavel K.; Afonin, Sergii; Ulrich, Anne S.; Komarov, Igor V.
Abstract: The article discusses research on trifluoromethylated phenylalanine analogue design, synthesis, and application as labels for solid-state fluorine-19 nuclear magnetic resonance (F NMR) spectroscopy. It cites use of trifluoromethyl-substituted compounds as replacement for alipathic amino acids necessary in F NMR spectroscopy. It describes inter- and intramolecular interactions between phenylalanine and other aromatic residues. Brief details about the design of a novel F NMR label are offered.
Subjects: PHENYLALANINE; NUCLEAR magnetic resonance spectroscopy; AMINO acids; FLUORINE; SOLID state chemistry
Publication: Angewandte Chemie, 2013, Vol 125, Issue 25, p6632
ISSN: 0044-8249
Publication type: Academic Journal
DOI: 10.1002/ange.201301344

Design, Synthesis, and Application of a Trifluoromethylated Phenylalanine Analogue as a Label to Study Peptides by Solid-State <sup>19</sup>F NMR Spectroscopy.

Tkachenko, Anton N.; Radchenko, Dmytro S.; Mykhailiuk, Pavel K.; Afonin, Sergii; Ulrich, Anne S.; Komarov, Igor V.