Title: Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients.
Authors: Dutta, Ranjan; Chang, Ansi; Doud, Mary K.; Kidd, Grahame J.; Ribaudo, Michael V.; Young, Elizabeth A.; Fox, Robert J.; Staugaitis, Susan M.; Trapp, Bruce D.
Abstract: The article presents a study on the molecular basis of memory dysfunction in patients with multiple sclerosis (MS). The study compared molecular and morphological changes in demyelinated and myelinated hippocampi from postmortem MS brains to investigate possible mechanisms of memory impairment in patients with MS. Results show that minimal neuronal loss occurred in demyelinated hippocampi but significant decrease in neuronal proteins essential for memory or learning, axonal transport were noted.
Subjects: MULTIPLE sclerosis; MEMORY disorders; HIPPOCAMPUS diseases; DEMYELINATION; MYELINATION; MEMORY; AXONAL transport; PATIENTS
Publication: Annals of Neurology, 2011, Vol 69, Issue 3, p445
ISSN: 0364-5134
Publication type: Academic Journal
DOI: 10.1002/ana.22337

Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients.

Dutta, Ranjan; Chang, Ansi; Doud, Mary K.; Kidd, Grahame J.; Ribaudo, Michael V.; Young, Elizabeth A.; Fox, Robert J.; Staugaitis, Susan M.; Trapp, Bruce D.