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In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline.
- Published in:
- Science Translational Medicine, 2021, v. 13, n. 612, p. 1, doi. 10.1126/scitranslmed.abj2511
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- Publication type:
- Article
Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration.
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- Alzheimer's Research & Therapy, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13195-024-01510-y
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- Publication type:
- Article
Locus coeruleus integrity and left frontoparietal connectivity provide resilience against attentional decline in preclinical alzheimer's disease.
- Published in:
- Alzheimer's Research & Therapy, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13195-024-01485-w
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- Publication type:
- Article
Atrophy links lower novelty‐related locus coeruleus connectivity to cognitive decline in preclinical AD.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 6, p. 3958, doi. 10.1002/alz.13839
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- Publication type:
- Article
Study design and methods: U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER).
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 2, p. 769, doi. 10.1002/alz.13365
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- Publication type:
- Article
User experience and biomarker associations of remotely administered and unsupervised smartphone‐based cognitive testing in a community sample of older adults.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.083050
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- Publication type:
- Article
Development and Validation of the Modified Neuropsychological Test Battery (PmNTB) in the Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER).
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.083038
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- Publication type:
- Article
Background and Design of the U.S. Study to Protect Brain Health through Lifestyle Intervention to Reduce Risk (U.S. POINTER).
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082779
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- Publication type:
- Article
Comparing the effectiveness of a brief observational study protocol versus a telephone call for Alzheimer's disease prevention trial prescreening.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082745
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- Publication type:
- Article
A brief questionnaire of self‐reported cognitive decline predicts MMSE and study partner QDRS: findings from the Davis Memory and Aging Cohort at Mass General Brigham.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082511
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- Publication type:
- Article
Prevalence and type of subjective cognitive concerns among participants at baseline and their relationship to cognition and other factors.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076643
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- Publication type:
- Article
Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28986-2
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- Publication type:
- Article
Monthly At-Home Computerized Cognitive Testing to Detect Diminished Practice Effects in Preclinical Alzheimer's Disease.
- Published in:
- Frontiers in Aging Neuroscience, 2022, v. 13, p. 1, doi. 10.3389/fnagi.2021.800126
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- Publication type:
- Article
Early Detection of Amyloid‐Related Changes in Memory among Cognitively Unimpaired Older Adults with Daily Digital Testing.
- Published in:
- Annals of Neurology, 2024, v. 95, n. 3, p. 507, doi. 10.1002/ana.26833
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- Publication type:
- Article
The impact of amyloid-beta and tau on prospective cognitive decline in older individuals.
- Published in:
- 2019
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- Publication type:
- journal article
Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline.
- Published in:
- 2017
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- Publication type:
- journal article
Amyloid and tau burden relate to longitudinal changes in the performance of complex everyday activities among cognitively unimpaired older adults: results from the performance-based Harvard Automated Phone Task.
- Published in:
- Frontiers in Aging Neuroscience, 2024, p. 1, doi. 10.3389/fnagi.2024.1420290
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- Publication type:
- Article
Detecting Subtle Changes in Visuospatial Executive Function and Learning in the Amnestic Variant of Mild Cognitive Impairment.
- Published in:
- PLoS ONE, 2011, v. 6, n. 7, p. 1, doi. 10.1371/journal.pone.0021688
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- Publication type:
- Article
Relationship between baseline levels of subjective cognitive concern and physical, cognitive and social activity in the U.S. POINTER Study.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080148
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- Publication type:
- Article
Validation of a Video Adaptation of the UDSv3 Cognitive Battery (VCog): Study Design and Preliminary Participant Satisfaction Results.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079840
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- Publication type:
- Article
Longitudinal multi‐day learning curves (MDLCs) to capture subtle cognitive changes in preclinical Alzheimer's disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078818
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- Publication type:
- Article
Self‐appraisal of cognitive performance in repeated daily digital assessments with amyloid and tau‐PET.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078386
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- Publication type:
- Article
Detecting Alzheimer's risk with cognitive dispersion on neuropsychological testing.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077951
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- Publication type:
- Article
Relationship between depressive symptoms and cognitive function in the U.S. POINTER study.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076992
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- Publication type:
- Article
The Mobile Toolbox for assessing cognition in older adults: associations with standardized cognitive testing and amyloid and tau PET.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.073522
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- Publication type:
- Article
Braak‐stage II atrophy links lower locus coeruleus – medial temporal lobe connectivity to cognitive decline in preclinical AD.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079240
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- Publication type:
- Article
Systemic vascular risk, white matter injury, and relative cerebral blood flow independently contribute to cognitive decline beyond amyloid and tau burden.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077904
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- Publication type:
- Article
Cohort heterogeneity and AD biomarkers in older adults without significant cognitive impairment: A comparison of U.S. POINTER and ADNI.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080245
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- Publication type:
- Article
Left Frontoparietal Connectivity Counteracts Locus Coeruleus‐Related Attentional Decline in Preclinical Alzheimer's Disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079733
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- Publication type:
- Article
Examining the influence of changes in amyloid burden on both contemporaneous and subsequent cognitive decline: using a latent change score approach.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078893
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- Publication type:
- Article
Spatiotemporal Assessment of Locus Coeruleus Integrity Predicting Cortical Tau and Cognition.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079747
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- Publication type:
- Article
Parental history of memory impairment predicts β‐amyloid burden and positivity in a preclinical population.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078420
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- Publication type:
- Article
Cohort heterogeneity and AD biomarkers in older adults without significant cognitive impairment: A comparison of U.S. POINTER and ADNI.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081990
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- Publication type:
- Article
Examining the influence of changes in amyloid burden on both contemporaneous and subsequent cognitive decline: using a latent change score approach.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081851
- By:
- Publication type:
- Article
Parental history of memory impairment predicts β‐amyloid burden and positivity in a preclinical population.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081812
- By:
- Publication type:
- Article
Spatiotemporal Assessment of Locus Coeruleus Integrity Predicting Cortical Tau and Cognition.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079747
- By:
- Publication type:
- Article
Parental history of memory impairment predicts β‐amyloid burden and positivity in a preclinical population.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078420
- By:
- Publication type:
- Article
Relation of modifiable lifestyle and mood factors to subjective cognitive concerns among participants and their study partners in the A4 screen data.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.062468
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- Publication type:
- Article
Why a clinical trial is as good as its outcome measure: A framework for the selection and use of cognitive outcome measures for clinical trials of Alzheimer's disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 2, p. 708, doi. 10.1002/alz.12773
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- Publication type:
- Article
Smartphone‐based long‐term delayed memory performance is associated with the Preclinical Alzheimer's Cognitive Composite and CSF levels of β‐amyloid.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 7, p. 1, doi. 10.1002/alz.067920
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- Publication type:
- Article
Lower novelty‐related locus coeruleus function is associated with entorhinal tau‐mediated memory decline in older individuals.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 7, p. 1, doi. 10.1002/alz.067706
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- Publication type:
- Article
Fluctuations in reaction time performance as a marker of incipient amyloid‐related cognitive decline in clinically unimpaired older adults.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 7, p. 1, doi. 10.1002/alz.066578
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- Publication type:
- Article
A simple, automated, speech‐based and AI‐enhanced screener for mild cognitive impairment and amyloid beta positivity.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 7, p. 1, doi. 10.1002/alz.065647
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- Publication type:
- Article
Assessing everyday functioning using a novel smartphone app in cognitively normal adults: A pilot study of the Assessment of Smartphone Everyday Tasks (ASSET).
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 7, p. 1, doi. 10.1002/alz.063844
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- Publication type:
- Article
Short‐term cognitive practice effects and their relation to amyloid and tau in preclinical Alzheimer's disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 7, p. 1, doi. 10.1002/alz.063764
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- Publication type:
- Article
Using a digital assessment of multi‐day learning curves to detect preclinical AD.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 7, p. 1, doi. 10.1002/alz.062194
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- Publication type:
- Article
Boston Remote Assessment for Neurocognitive Health in preclinical AD.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 7, p. 1, doi. 10.1002/alz.059636
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- Publication type:
- Article
Longitudinal hippocampal atrophy is associated with cognitive decline independently of amyloid and tau in neocortex.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 6, p. 1, doi. 10.1002/alz.069271
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- Publication type:
- Article
Defining the ATN framework using longitudinal biomarker trajectories reveals an emerging amyloid accumulation group.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 6, p. 1, doi. 10.1002/alz.068001
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- Publication type:
- Article
The role of cortical microstructural changes on longitudinal accumulation of tau and cognitive decline in at risk older adults.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 5, p. 1, doi. 10.1002/alz.065744
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- Publication type:
- Article