One-Pot Synthesis of 2-Arylbenzoxazoles by Gas-Free Carbonylation using Dicobalt Octacarbonyl as a Solid Carbon Monoxide Source.

Baburajan, Poongavanam; Elango, Kuppanagounder P.

A simple, mild, and facile carbonylation procedure to synthesise 2-arylbenzoxazole derivatives using dicobalt octacarbonyl [Co2(CO)8] as an in situ carbon monoxide source is described. This method is tolerant of a variety of functional groups and the compounds are obtained in high to excellent yields. Moreover, the reaction is performed in one-pot with a simple workup procedure. The choice of catalytic system as well as base is important in order to ensure a high yield and chemoselectivity in the reaction. Both electron-rich and electron-deficient aryl bromides worked well in this reaction.

CARBONYLATION; CARBON monoxide; CHEMOSELECTIVITY; ARYL bromides; FUNCTIONAL groups

Asian Journal of Organic Chemistry, 2015, Vol 4, Issue 4, p354

2193-5807

Academic Journal

10.1002/ajoc.201402252