Development and Evaluations of Aceclofenac Microcapsules for Colon-Targeted Delivery: An In Vitro Study.

Farooq, Muhammad; Ahmad, Mahmood; Madni, Asadullah; Hanif, Muhammad; Khan, Muhammad Rizwan

ABSTRACT Microcapsules of aceclofenac with pH-dependent release properties for achieving targeted delivery to colon were developed. A solvent evaporation technique was adopted for microcapsules preparation using Eudragit RS 100 as a retardant polymer. The microcapsules were found free flowing, whitish, and spherical in shape. The entrapment efficacies of microcapsules were 95.73, 85.67, and 84% for F1 (1:1), F2 (1:2), and F3 (1:3), respectively. The particle size was in the range of 12 ± 2.48 to 32 ± 2.20 μm. The X-ray diffraction and Fourier transforms infrared (FTIR) studies of prepared microcapsules illustrated that there was no interaction between drug and polymer. The dissolution performed in three different pH media (1.2, 6.8, and 7.4) at 37 ± 0.5°C elucidates negligible release at pH 1.2 for 2 h but changing the pH from 1.2 to 6.8, showed burst release after 4 h and then demonstrated a constant release rate at 7.4 pH. The time for half-life of microcapsules showed that drug release from F1 microcapsules was quicker than F2 and F3. The time for half-life of capsule filled microcapsules was 15.54, 17.40, and 20.08 h, respectively. The formulated microcapsules do not show the release in gastric medium but released at phosphate buffer pH 6.8 and 7.4.

MOLECULAR capsules; SOLVENTS; EVAPORATION (Chemistry); PHOSPHATES; POLYMER research

Advances in Polymer Technology, 2015, Vol 34, Issue 2, pn/a

0730-6679

Academic Journal

10.1002/adv.21482