Results
Title

Copper-Catalyzed Domino S<sub>N</sub>2′/Coupling Reaction: A Versatile and Facile Synthesis of Cyclic Compounds from Baylis-Hillman Acetates.

Authors

Niu, Qingsheng; Mao, Hui; Yuan, Guodong; Gao, Jilong; Liu, Haiquan; Tu, Yawei; Wang, Xiaoxia; Lv, Xin

Abstract

A variety of substituted quinoline/pyridine, thiochromene and naphthalene derivatives, which might be of biological and medicinal value, were synthesized by copper-catalyzed domino SN2′/coupling, SN2′/deacylation/coupling and SN2′/coupling/elimination reactions. The method provides a general and convenient approach to the synthesis of various substituted cyclic compounds from the corresponding Baylis-Hillman (B-H) acetates and N-/S-/C-nucleophiles.

Publication

Advanced Synthesis & Catalysis, 2013, Vol 355, Issue 6, p1185

ISSN

1615-4150

Publication type

Academic Journal

DOI

10.1002/adsc.201201033