Title: Computational DNA Droplets Recognizing miRNA Sequence Inputs Based on Liquid–Liquid Phase Separation (Adv. Funct. Mater. 37/2022).
Authors: Gong, Jing; Tsumura, Nozomi; Sato, Yusuke; Takinoue, Masahiro
Abstract: DNA computing, DNA droplets, liquid-liquid phase separation, molecular robots, tumor biomarker miRNA detection Keywords: DNA computing; DNA droplets; liquid-liquid phase separation; molecular robots; tumor biomarker miRNA detection EN DNA computing DNA droplets liquid-liquid phase separation molecular robots tumor biomarker miRNA detection 1 1 1 09/14/22 20220912 NES 220912 B Computational DNA Droplets b In article number 2202322, Masahiro Takinoue and co-workers develop a computational DNA droplet using programmable phase-separated droplets consisting of DNA nanostructures. They demonstrate that the computational DNA droplet can recognize a specific combination of tumor marker microRNAs as molecular inputs and output results of DNA logic operations through DNA droplet division, achieving the fusion of biosensing and molecular computation in DNA droplets.
Subjects: PHASE separation; DNA; MICRORNA; DROPLETS
Publication: Advanced Functional Materials, 2022, Vol 32, Issue 37, p1
ISSN: 1616-301X
Publication type: Academic Journal
DOI: 10.1002/adfm.202270206

Computational DNA Droplets Recognizing miRNA Sequence Inputs Based on Liquid–Liquid Phase Separation (Adv. Funct. Mater. 37/2022).

Gong, Jing; Tsumura, Nozomi; Sato, Yusuke; Takinoue, Masahiro