We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthetic Biology: Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains (Adv. Funct. Mater. 34/2014).
- Authors
Pastuszka, Martha K.; Okamoto, Curtis T.; Hamm‐Alvarez, Sarah F.; MacKay, J. Andrew
- Abstract
Elastin‐like polypeptides can be expressed in eukaryotic cells in fusion with functional proteins. When heated, they assemble organelle‐sized microdomains that sequester target complexes. On page 5340, J. A. MacKay and team demonstrate that, by fusion to clathrin‐light chain, these microdomains co‐localize and sequester clathrin heavy chain, which is necessary for clathrin‐mediated endocytosis. Assembly rapidly and reversibly blocks internalization of G‐protein coupled receptors. Image created by Isaac Mora.
- Subjects
PERIODICALS; MATERIALS science periodicals
- Publication
Advanced Functional Materials, 2014, Vol 24, Issue 34, p5309
- ISSN
1616-301X
- Publication type
Academic Journal
- DOI
10.1002/adfm.201470224