Works matching DE "DYSTROPHIN genes"

Results: 322

Diversity of Dystrophin Gene Mutations and Disease Progression in a Contemporary Cohort of Duchenne Muscular Dystrophy.

Published in:

Pediatric Cardiology, 2022, v. 43, n. 4, p. 855, doi. 10.1007/s00246-021-02797-6

By:

Gambetta, Katheryn E.;
McCulloch, Michael A.;
Lal, Ashwin K.;
Knecht, Kenneth;
Butts, Ryan J.;
Villa, Chet R.;
Johnson, Jonathan N.;
Conway, Jennifer;
Bock, Matthew J.;
Schumacher, Kurt R.;
Law, Sabrina P.;
Friedland-Little, Joshua M.;
Deshpande, Shriprasad R.;
West, Shawn C.;
Lytrivi, Irene D.;
Wittlieb-Weber, Carol A.

Publication type:

Article

DGGE-based whole-gene mutation scanning of the dystrophin gene in Duchenne and Becker muscular dystrophy patients (Communicated by Ulf Landegren).

Published in:

Human Mutation, 2004, v. 23, n. 1, p. 57, doi. 10.1002/humu.10283

By:

Robert M.W. Hofstra;
Inge M. Mulder;
Rolf Vossen;
Pia A. M. de Koning-Gans;
Marian Kraak;
Ieke B. Ginjaar;
Annemarie H. van der Hout;
Egbert Bakker;
Charles H.C.M. Buys;
Gert-Jan B. van Ommen;
Anthonie J. van Essen;
Johan T. den Dunnen

Publication type:

Article

Updates in the Use of Vamorolone and Steroids in the Treatment of Duchenne Muscular Dystrophy.

Published in:

touchREVIEWS in Neurology, 2023, v. 19, n. 2, p. 1, doi. 10.17925/USN.2023.19.2.5

By:

McGowan, Bridget;
Kuntz, Nancy L

Publication type:

Article

On genotype-phenotype relationship of dystrophinopathies among Iranian population.

Published in:

Current Journal of Neurology, 2023, v. 22, n. 4, p. 231, doi. 10.18502/cjn.v22i4.14528

By:

Basiri, Keivan;
Alizadeh, Maryam;
Ansari, Behnaz;
Ghasemi, Majid;
Kheradmand, Mohsen;
Sedghi, Maryam

Publication type:

Article

Exon Deletion Patterns of the Dystrophin Gene in 82 Vietnamese Duchenne/Becker Muscular Dystrophy Patients.

Published in:

Journal of Neurogenetics, 2013, v. 27, n. 4, p. 170, doi. 10.3109/01677063.2013.830616

By:

Tran, Van Khanh;
Ta, Van Thanh;
Vu, Dung Chi;
Nguyen, Suong Thi-Bang;
Do, Hai Ngoc;
Ta, Minh Hieu;
Tran, Thinh Huy;
Matsuo, Masafumi

Publication type:

Article

Duchenne muscular dystrophy: preliminary experience with sacubitril-valsartan in patients with asymptomatic left ventricular dysfunction.

Published in:

European Review for Medical & Pharmacological Sciences, 2020, v. 24, n. 17, p. 9112

By:

LAMENDOLA, P.;
LANZA, G. A.;
MELITA, V.;
VILLANO, A.;
PALERMO, C.;
LEONE, D.;
LOMBARDO, A.;
PENNESTRÌ, F.;
CREA, F.;
MERCURI, E. M.;
PANE, M.

Publication type:

Article

Duchenne muscular dystrophy trajectory in R-DMDdel52 preclinical rat model identifies COMP as biomarker of fibrosis.

Published in:

Acta Neuropathologica Communications, 2022, v. 10, n. 1, p. 1, doi. 10.1186/s40478-022-01355-2

By:

Taglietti, Valentina;
Kefi, Kaouthar;
Bronisz-Budzyńska, Iwona;
Mirciloglu, Busra;
Rodrigues, Mathilde;
Cardone, Nastasia;
Coulpier, Fanny;
Periou, Baptiste;
Gentil, Christel;
Goddard, Melissa;
Authier, François-Jérôme;
Pietri-Rouxel, France;
Malfatti, Edoardo;
Lafuste, Peggy;
Tiret, Laurent;
Relaix, Frederic

Publication type:

Article

Autophagy in the heart is enhanced and independent of disease progression in mus musculus dystrophinopathy models.

Published in:

JRSM Cardiovascular Disease, 2019, v. 8, p. N.PAG, doi. 10.1177/2048004019879581

By:

Spaulding, HR;
Ballmann, C;
Quindry, JC;
Hudson, MB;
Selsby, JT

Publication type:

Article

Advances in Dystrophinopathy Diagnosis and Therapy.

Published in:

Biomolecules (2218-273X), 2023, v. 13, n. 9, p. 1319, doi. 10.3390/biom13091319

By:

Saad, Fawzy A.;
Siciliano, Gabriele;
Angelini, Corrado

Publication type:

Article

Design of bacteriophage T4-based artificial viral vectors for human genome remodeling.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-38364-1

By:

Zhu, Jingen;
Batra, Himanshu;
Ananthaswamy, Neeti;
Mahalingam, Marthandan;
Tao, Pan;
Wu, Xiaorong;
Guo, Wenzheng;
Fokine, Andrei;
Rao, Venigalla B.

Publication type:

Article

Myocardial Contractile Dysfunction Is Present without Histopathology in a Mouse Model of Limb-Girdle Muscular Dystrophy-2F and Is Prevented after Claudin-5 Virotherapy.

Published in:

Frontiers in Physiology, 2016, v. 7, p. 1, doi. 10.3389/fphys.2016.00539

By:

Milani-Nejad, Nima;
Schultz, Eric J.;
Slabaugh, Jessica L.;
Janssen, Paul M. L.;
Rafael-Fortney, Jill A.

Publication type:

Article

An Updated Analysis of Exon-Skipping Applicability for Duchenne Muscular Dystrophy Using the UMD-DMD Database.

Published in:

Genes, 2024, v. 15, n. 11, p. 1489, doi. 10.3390/genes15111489

By:

Leckie, Jamie;
Zia, Abdullah;
Yokota, Toshifumi

Publication type:

Article

Spectrum of Genetic Variants in the Dystrophin Gene: A Single Centre Retrospective Analysis of 750 Duchenne and Becker Patients from Southern Italy.

Published in:

Genes, 2023, v. 14, n. 1, p. 214, doi. 10.3390/genes14010214

By:

Viggiano, Emanuela;
Picillo, Esther;
Passamano, Luigia;
Onore, Maria Elena;
Piluso, Giulio;
Scutifero, Marianna;
Torella, Annalaura;
Nigro, Vincenzo;
Politano, Luisa

Publication type:

Article

Antisense and Gene Therapy Options for Duchenne Muscular Dystrophy Arising from Mutations in the N-Terminal Hotspot.

Published in:

Genes, 2022, v. 13, n. 2, p. 257, doi. 10.3390/genes13020257

By:

Wilton-Clark, Harry;
Yokota, Toshifumi

Publication type:

Article

Splicing Characteristics of Dystrophin Pseudoexons and Identification of a Novel Pathogenic Intronic Variant in the DMD Gene.

Published in:

Genes, 2020, v. 11, n. 10, p. 1180, doi. 10.3390/genes11101180

By:

Xie, Zhiying;
Tang, Liuqin;
Xie, Zhihao;
Sun, Chengyue;
Shuai, Haoyue;
Zhou, Chao;
Liu, Yilin;
Yu, Meng;
Zheng, Yiming;
Meng, Lingchao;
Zhang, Wei;
Leal, Suzanne M.;
Wang, Zhaoxia;
Schrauwen, Isabelle;
Yuan, Yun

Publication type:

Article

Therapeutic Strategies for Duchenne Muscular Dystrophy: An Update.

Published in:

Genes, 2020, v. 11, n. 8, p. 837, doi. 10.3390/genes11080837

By:

Sun, Chengmei;
Shen, Luoan;
Zhang, Zheng;
Xie, Xin

Publication type:

Article

Cardiac Involvement in Dystrophin-Deficient Females: Current Understanding and Implications for the Treatment of Dystrophinopathies.

Published in:

Genes, 2020, v. 11, n. 7, p. 765, doi. 10.3390/genes11070765

By:

Lim, Kenji Rowel Q.;
Sheri, Narin;
Nguyen, Quynh;
Yokota, Toshifumi

Publication type:

Article

Copy Number Variants Account for a Tiny Fraction of Undiagnosed Myopathic Patients.

Published in:

Genes, 2018, v. 9, n. 11, p. 524, doi. 10.3390/genes9110524

By:

Giugliano, Teresa;
Savarese, Marco;
Garofalo, Arcomaria;
Picillo, Esther;
Fiorillo, Chiara;
D'Amico, Adele;
Maggi, Lorenzo;
Ruggiero, Lucia;
Vercelli, Liliana;
Magri, Francesca;
Fattori, Fabiana;
Torella, Annalaura;
Ergoli, Manuela;
Rubegni, Anna;
Fanin, Marina;
Musumeci, Olimpia;
Bleecker, Jan De;
Peverelli, Lorenzo;
Moggio, Maurizio;
Mercuri, Eugenio

Publication type:

Article

Exonization of an Intronic LINE-1 Element Causing Becker Muscular Dystrophy as a Novel Mutational Mechanism in Dystrophin Gene.

Published in:

Genes, 2017, v. 8, n. 10, p. 253, doi. 10.3390/genes8100253

By:

Gonçalves, Ana;
Oliveira, Jorge;
Coelho, Teresa;
Taipa, Ricardo;
Melo-Pires, Manuel;
Sousa, Mário;
Santos, Rosário

Publication type:

Article

Caveolin 3 gene and mitochondrial tRNA methionin gene in Duchenne muscular dystrophy.

Published in:

Egyptian Journal of Medical Human Genetics, 2009, v. 10, n. 2, p. 154

By:

Abdel-Meguid, Iman E.;
Korraa, Soheir S.;
Abdel-Salam, Ekram

Publication type:

Article

Cytokines and growth factors in Duchene muscular dystrophy patients.

Published in:

Egyptian Journal of Medical Human Genetics, 2008, v. 9, n. 2, p. 181

By:

Abdel-Meguid, Iman;
Abdel-Salam, Ekram;
Korraa, Soheir

Publication type:

Article

Determination of qPCR reference genes suitable for normalizing gene expression in a novel model of Duchenne muscular dystrophy, the D2-mdx mouse.

Published in:

PLoS ONE, 2024, v. 19, n. 11, p. 1, doi. 10.1371/journal.pone.0310714

By:

Boccanegra, Brigida;
Lenti, Roberta;
Mantuano, Paola;
Conte, Elena;
Tulimiero, Lisamaura;
Piercy, Richard J.;
Cappellari, Ornella;
Hildyard, John C. W.;
De Luca, Annamaria

Publication type:

Article

Mechanisms and Consequences of Cerebellar Purkinje Cell Disinhibition in a Mouse Model of Duchenne Muscular Dystrophy.

Published in:

Journal of Neuroscience, 2022, v. 42, n. 10, p. 2103, doi. 10.1523/JNEUROSCI.1256-21.2022

By:

Wan-Chen Wu;
Bradley, Samual P.;
Christie, Jason M.;
Pugh, Jason R.

Publication type:

Article

Dystrophin and utrophin 'double knockout' dystrophic mice exhibit a spectrum of degenerative musculoskeletal abnormalities.

Published in:

Journal of Orthopaedic Research, 2013, v. 31, n. 3, p. 343, doi. 10.1002/jor.22236

By:

Isaac, Christian;
Wright, Adam;
Usas, Arvydas;
Li, Hongshuai;
Tang, Ying;
Mu, Xiaodong;
Greco, Nicholas;
Dong, Qing;
Vo, Nam;
Kang, James;
Wang, Bing;
Huard, Johnny

Publication type:

Article

Systemic human minidystrophin gene transfer improves functions and life span of dystrophin and dystrophin/utrophin-deficient mice.

Published in:

Journal of Orthopaedic Research, 2009, v. 27, n. 4, p. 421, doi. 10.1002/jor.20781

By:

Wang, Bing;
Li, Juan;
Fu, Freddie H.;
Xiao, Xiao

Publication type:

Article

Early Cardiac Dysfunction in Duchenne Muscular Dystrophy: A Case Report and Literature Update.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 4, p. 1685, doi. 10.3390/ijms26041685

By:

Lupu, Maria;
Pintilie, Iustina Mihaela;
Teleanu, Raluca Ioana;
Marin, Georgiana Gabriela;
Vladâcenco, Oana Aurelia;
Severin, Emilia Maria

Publication type:

Article

In Vitro Gene Therapy Using Human iPS-Derived Mesoangioblast-Like Cells (HIDEMs) Combined with Microdystrophin (μDys) Expression as the New Strategy for Duchenne Muscular Dystrophy (DMD) Experimental Treatment.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 22, p. 11869, doi. 10.3390/ijms252211869

By:

Budzińska, Marta;
Malcher, Agnieszka;
Zimna, Agnieszka;
Kurpisz, Maciej

Publication type:

Article

De Novo p.Asp3368Gly Variant of Dystrophin Gene Associated with X-Linked Dilated Cardiomyopathy and Skeletal Myopathy: Clinical Features and In Silico Analysis.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 5, p. 2787, doi. 10.3390/ijms25052787

By:

d'Apolito, Maria;
Ranaldi, Alessandra;
Santoro, Francesco;
Cannito, Sara;
Gravina, Matteo;
Santacroce, Rosa;
Ragnatela, Ilaria;
Margaglione, Alessandra;
D'Andrea, Giovanna;
Casavecchia, Grazia;
Brunetti, Natale Daniele;
Margaglione, Maurizio

Publication type:

Article

Modeling Duchenne Muscular Dystrophy Cardiomyopathy with Patients' Induced Pluripotent Stem-Cell-Derived Cardiomyocytes.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 10, p. 8657, doi. 10.3390/ijms24108657

By:

Eisen, Binyamin;
Binah, Ofer

Publication type:

Article

Bioenergetic and Metabolic Impairments in Induced Pluripotent Stem Cell-Derived Cardiomyocytes Generated from Duchenne Muscular Dystrophy Patients.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 17, p. 9808, doi. 10.3390/ijms23179808

By:

Willi, Lubna;
Abramovich, Ifat;
Fernandez-Garcia, Jonatan;
Agranovich, Bella;
Shulman, Margarita;
Milman, Helena;
Baskin, Polina;
Eisen, Binyamin;
Michele, Daniel E.;
Arad, Michael;
Binah, Ofer;
Gottlieb, Eyal

Publication type:

Article

Integrating Whole-Genome Sequencing in Clinical Genetics: A Novel Disruptive Structural Rearrangement Identified in the Dystrophin Gene (DMD).

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 1, p. 59, doi. 10.3390/ijms23010059

By:

Gonçalves, Ana;
Fortuna, Ana;
Ariyurek, Yavuz;
Oliveira, Márcia E.;
Nadais, Goreti;
Pinheiro, Jorge;
den Dunnen, Johan T.;
Sousa, Mário;
Oliveira, Jorge;
Santos, Rosário

Publication type:

Article

Natural History of a Mouse Model Overexpressing the Dp71 Dystrophin Isoform.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 23, p. 12617, doi. 10.3390/ijms222312617

By:

Lim, Kenji Rowel Q.;
Shah, Md Nur Ahad;
Woo, Stanley;
Wilton-Clark, Harry;
Zhabyeyev, Pavel;
Wang, Faqi;
Maruyama, Rika;
Oudit, Gavin Y.;
Yokota, Toshifumi

Publication type:

Article

First Identification of RNA-Binding Proteins That Regulate Alternative Exons in the Dystrophin Gene.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 20, p. 7803, doi. 10.3390/ijms21207803

By:

Miro, Julie;
Bougé, Anne-Laure;
Murauer, Eva;
Beyne, Emmanuelle;
Da Cunha, Dylan;
Claustres, Mireille;
Koenig, Michel;
Tuffery-Giraud, Sylvie

Publication type:

Article

Multi-Compartment, Early Disruption of cGMP and cAMP Signalling in Cardiac Myocytes from the mdx Model of Duchenne Muscular Dystrophy.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 19, p. 7056, doi. 10.3390/ijms21197056

By:

Brescia, Marcella;
Chao, Ying-Chi;
Koschinski, Andreas;
Tomek, Jakub;
Zaccolo, Manuela

Publication type:

Article

miRNA Profiling for Early Detection and Treatment of Duchenne Muscular Dystrophy.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 18, p. 4638, doi. 10.3390/ijms20184638

By:

Hrach, Heather C.;
Mangone, Marco

Publication type:

Article

Modulation of Protein Quality Control and Proteasome to Autophagy Switch in Immortalized Myoblasts from Duchenne Muscular Dystrophy Patients.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 1, p. 178, doi. 10.3390/ijms19010178

By:

Wattin, Marion;
Gaweda, Loïc;
Muller, Pascale;
Baritaud, Mathieu;
Scholtes, Charlotte;
Lozano, Chloé;
Gieseler, Kathrin;
Kretz-Remy, Carole

Publication type:

Article

Clinical and Molecular Profile of Duchenne Muscular Dystrophy (DMD): Case-Record Analysis From Uttar Pradesh, India.

Published in:

Indian Pediatrics, 2024, v. 61, n. 12, p. 1119, doi. 10.1007/s13312-024-3333-7

By:

Singh, Ankur;
Sidar, Minketan;
Ali, Akhtar;
Abhinay, Abhishek;
Prasad, Rajniti;
Mishra, Om Prakash

Publication type:

Article

Duchenne Muscular Dystrophy — Renewed Enthusiasm as We Enter the Era of Therapeutics!

Published in:

Indian Pediatrics, 2024, v. 61, n. 12, p. 1093, doi. 10.1007/s13312-024-3327-5

By:

Bijarnia-Mahay, Sunita

Publication type:

Article

Detection of mutations in the dystrophin gene via automated DHPLC screening and direct sequencing.

Published in:

BMC Genetics, 2001, v. 2, p. 17, doi. 10.1186/1471-2156-2-17

By:

Bennett, Richard R.;
Den Dunnen, Johan;
O'Brien, Kristine F.;
Darras, Basil T.;
Kunkel, Louis M.

Publication type:

Article

Comparative study of mesenchymal stem cells from C57BL/10 and mdx mice.

Published in:

BMC Cell Biology, 2008, v. 9, p. 1, doi. 10.1186/1471-2121-9-24

By:

Yong Li;
Cheng Zhang;
Fu Xiong;
Mei-juan Yu;
Fu-lin Peng;
Yanchang Shang;
Cui-ping Zhao;
Yong-feng Xu;
Zheng-shan Liu;
Chang Zhou;
Jin-lang Wu

Publication type:

Article

Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-beta.

Published in:

2009

By:

Vetrone, Sylvia A.;
Montecino-Rodriguez, Encarnacion;
Kudryashova, Elena;
Kramerova, Irina;
Hoffman, Eric P.;
Liu, Scot D.;
Miceli, M. Carrie;
Spencer, Melissa J.

Publication type:

journal article

Dysferlin-mediated membrane repair protects the heart from stress-induced left ventricular injury.

Published in:

Journal of Clinical Investigation, 2007, v. 117, p. 1805, doi. 10.1172/JCI30848

By:

Han, Renzhi;
Bansal, Dimple;
Miyake, Katsuya;
Muniz, Viviane P.;
Weiss, Robert M.;
McNeil, Paul L.;
Campbell, Kevin P.

Publication type:

Article

MUTATION ANALYSIS OF DYSTROPHIN GENE IN MALAYSIAN DUCHENNE MUSCULAR DYSTROPHY (DMD) PATIENTS.

Published in:

Malaysian Journal of Medical Sciences, 2008, p. 28

By:

R., Mahyoob;
M. K., Zahri;
M., Marini;
A. A., Salmi;
M. D., Siti Mardzia;
A. M. H., Zabidi-Husin;
B. A., Zilfalil

Publication type:

Article

Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition.

Published in:

Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-04666-9

By:

Gleneadie, Hannah J.;
Fernandez-Ruiz, Beatriz;
Sardini, Alessandro;
Van de Pette, Mathew;
Dimond, Andrew;
Prinjha, Rab K.;
McGinty, James;
French, Paul M. W.;
Bagci, Hakan;
Merkenschlager, Matthias;
Fisher, Amanda G.

Publication type:

Article

Viltolarsen in Japanese Duchenne muscular dystrophy patients: A phase 1/2 study.

Published in:

Annals of Clinical & Translational Neurology, 2020, v. 7, n. 12, p. 2393, doi. 10.1002/acn3.51235

By:

Komaki, Hirofumi;
Takeshima, Yasuhiro;
Matsumura, Tsuyoshi;
Ozasa, Shiro;
Funato, Michinori;
Takeshita, Eri;
Iwata, Yasuyuki;
Yajima, Hiroyuki;
Egawa, Yoichi;
Toramoto, Takuya;
Tajima, Masaya;
Takeda, Shinichi

Publication type:

Article

Case Report: Identification of Maternal Low-Level Mosaicism in the Dystrophin Gene by Droplet Digital Polymerase Chain Reaction.

Published in:

Frontiers in Genetics, 2021, v. 11, p. 1, doi. 10.3389/fgene.2021.686993

By:

Jin, Pengzhen;
Gao, Xiaoyang;
Wang, Miaomiao;
Qian, Yeqing;
Yang, Jingjin;
Yang, Yanmei;
Xu, Yuqing;
Xu, Yanfei;
Dong, Minyue

Publication type:

Article

Multiplex Ligation Dependent Probe Amplification Based Mutation Analysis of Dystrophin Gene in Nepalese Patients with Duchenne Muscular Dystrophy.

Published in:

Nepal Journal of Biotechnology, 2016, v. 4, n. 1, p. 37, doi. 10.3126/njb.v4i1.16345

By:

Shrestha, Kushal;
Shrestha, Smita;
Khatiwada, Saroj;
Acharya, Bishnu;
Manandhar, Sulochana;
Pokharel, Rohit Kumar

Publication type:

Article

PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy.

Published in:

Frontiers in Physiology, 2020, v. 11, p. 1, doi. 10.3389/fphys.2020.00403

By:

Farini, Andrea;
Villa, Chiara;
Di Silvestre, Dario;
Bella, Pamela;
Tripodi, Luana;
Rossi, Rossana;
Sitzia, Clementina;
Gatti, Stefano;
Mauri, Pierluigi;
Torrente, Yvan

Publication type:

Article

Duchenne muscular dystrophy: A immunohistochemical profile and deletion pattern in dystrophin gene in North Indian population.

Published in:

Asian Journal of Medical Sciences, 2017, v. 8, n. 6, p. 13, doi. 10.3126/ajms.v8i6.18281

By:

Agarwal, Rachna;
Chaturvedi, Sujata;
Chhillar, Neelam;
Pant, Ishita;
Sharma, Anuradha

Publication type:

Article

Genetic Profile of the Dystrophin Gene Reveals New Mutations in Colombian Patients Affected with Muscular Dystrophinopathy.

Published in:

Application of Clinical Genetics, 2021, v. 14, p. 399, doi. 10.2147/TACG.S317721

By:

Triana-Fonseca, Paula;
Parada-Márquez, Juan Fernando;
Silva-Aldana, Claudia T;
Zambrano-Arenas, Daniela;
Arias-Gomez, Laura Lucia;
Morales-Fonseca, Natalia;
Medina-Méndez, Esteban;
Restrepo, Carlos M;
Silgado-Guzmán, Daniel Felipe;
Fonseca-Mendoza, Dora Janeth

Publication type:

Article