Lateral hypothalamic activity indicates hunger and satiety states in humans.

Talakoub, Omid; Paiva, Raquel R.; Milosevic, Matija; Hoexter, Marcelo Q.; Franco, Ruth; Alho, Eduardo; Navarro, Jessie; Pereira, José F.; Popovic, Milos R.; Savage, Cary; Lopes, Antonio C.; Alvarenga, Pedro; Damiani, Durval; Teixeira, Manoel J.; Miguel, Euripides C.; Fonoff, Erich T.; Batistuzzo, Marcelo C.; Hamani, Clement

Lateral hypothalamic area (LHA) local field potentials (LFPs) were recorded in a Prader-Willi patient undergoing deep brain stimulation (DBS) for obesity. During hunger, exposure to food-related cues induced an increase in beta/low-gamma activity. In contrast, recordings during satiety were marked by prominent alpha rhythms. Based on these findings, we have delivered alphafrequency DBS prior to and during food intake. Despite reporting an early sensation of fullness, the patient continued to crave food. This suggests that the pattern of activity in LHA may indicate hunger/satiety states in humans but attest to the complexity of conducting neuromodulation studies in obesity.

PRADER-Willi syndrome; ALPHA rhythm; OBESITY; FOOD consumption; DEEP brain stimulation

Annals of Clinical & Translational Neurology, 2017, Vol 4, Issue 12, p897

2328-9503

Academic Journal

10.1002/acn3.466