Title: Irregular distribution of cytochrome c oxidase protein subunits in aging and Alzheimer's disease.
Authors: Ojaimi, Joseline; Masters, Colin L.; McLean, Catriona; Opeskin, Ken; McKelvie, Penny; Byrne, Edward
Abstract: This study aims to investigate the cellular distribution of human cytochrome c oxidase (COX) subunit II (CII) and COX subunit IV (CIV) in Alzheimer's disease relative to control brains. The levels of CIV and CII proteins in the cerebellar Purkinje cells were reduced in age-matched controls relative to young controls and in the Alzheimer's disease group relative to both age-matched and young controls. Results suggest that these age-associated changes are more marked in Alzheimer's disease.
Publication: Annals of Neurology, 1999, Vol 46, Issue 4, p656
ISSN: 0364-5134
Publication type: Academic Journal
DOI: 10.1002/1531-8249(199910)46:4<656::AID-ANA16>3.0.CO;2-Q

Irregular distribution of cytochrome c oxidase protein subunits in aging and Alzheimer's disease.

Ojaimi, Joseline; Masters, Colin L.; McLean, Catriona; Opeskin, Ken; McKelvie, Penny; Byrne, Edward