Title: Possible relationships between plasma carbamazepine-10,11-epoxide levels and antimanic efficacy and side effects in patients with schizoaffective disorde.
Authors: Yoshimura, Reiji; Nakamura, Jun; Eto, Seiji; Ueda, Nobuhisa
Abstract: We examined the relationships of plasma levels of carbamazepine (CBZ) and its two major metabolites, carbamazepine-10,11-epoxide (CBZ-E) and carbamazepine-10,11-diol (CBZ-D), with antimanic efficacy and side effects in patients with schizoaffective disorder. Positive relationships were found among plasma concentrations of CBZ-E and the degree of clinical improvement and side effects, whereas neither plasma CBZ nor CBZ-D levels were correlated with the degree of clinical improvement or side effects. Copyright © 2000 John Wiley & Sons, Ltd.
Subjects: CARBAMAZEPINE; DRUG side effects; BLOOD plasma; METABOLITES; SCHIZOAFFECTIVE disorders
Publication: Human Psychopharmacology: Clinical & Experimental, 2000, Vol 15, Issue 4, p237
ISSN: 0885-6222
Publication type: Academic Journal
DOI: 10.1002/1099-1077(200006)15:4<237::AID-HUP160>3.0.CO;2-5

Possible relationships between plasma carbamazepine-10,11-epoxide levels and antimanic efficacy and side effects in patients with schizoaffective disorde.

Yoshimura, Reiji; Nakamura, Jun; Eto, Seiji; Ueda, Nobuhisa